| Identification | Back Directory | [Name]
6,8-Diprenylorobol | [CAS]
66777-70-6 | [Synonyms]
8-Diprenylorobol
6,8-Diprenylorobol
5,7,3',4'-Tetrahydroxy-6,8-diprenylisoflavone
4H-1-Benzopyran-4-one, 3-(3,4-dihydroxyphenyl)-5,7-dihydroxy-6,8-bis(3-methyl-2-buten-1-yl)- | [Molecular Formula]
C25H26O6 | [MDL Number]
MFCD23103683 | [MOL File]
66777-70-6.mol | [Molecular Weight]
422.47 |
| Chemical Properties | Back Directory | [Boiling point ]
667.1±55.0 °C(Predicted) | [density ]
1.301±0.06 g/cm3(Predicted) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
powder | [pka]
7.00±0.20(Predicted) | [color ]
Yellow |
| Hazard Information | Back Directory | [Uses]
6,8-Diprenylorobol, a prenylated isoflavone, is a nature product that could be isolated from the leaves of Cudrania tricuspidata. 6,8-Diprenylorobol antiproliferative effect and induces apoptosis through activation of p53 and generation of ROS[1][2]. | [target]
Estrogen receptor | Antifection | HIV | Progestogen receptor | [References]
[1] Choi YJ, et, al. 6,8-Diprenylorobol induces apoptosis in human colon cancer cells via activation of intracellular reactive oxygen species and p53. Environ Toxicol. 2021 May;36(5):914-925. DOI:10.1002/tox.23093
[2] Tuan Anh HL, et, al. Prenylated isoflavones from Cudrania tricuspidata inhibit NO production in RAW 264.7 macrophages and suppress HL-60 cells proliferation. J Asian Nat Prod Res. 2017 May;19(5):510-518. DOI:10.1080/10286020.2016.1232253 |
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