| Identification | Back Directory | [Name]
MICRONOMICIN SULFATE | [CAS]
66803-19-8 | [Synonyms]
MICRONOMICIN SULFATE
MICRONOMYCIN SULFATE
sulfate,d-1-6))-2-deoxy
Micronomicin Sulfate (~80%)
Micronomicin sulfate JAS1998
MICRONOMICIN SULFATE USP/EP/BP
Micronomicin Sulfate CAS: 66803-19-8
6'-N-METHYLGENTAMICIN C1A HEMIPENTASULFATE
streptamine,o-2-amino-2,3,4,6-tetradeoxy-6-(methylamino)-alpha-d-erythro-hexop
yranosyl-(1-4)-o-(3-deoxy-4-c-methyl-3-(methylamino)-beta-l-arabinopyranosyl-(
(2R,3R,4R,5R)-2-[(1S,2S,3R,4S,6R)-4,6-diamino-3-[(2R,3R,6S)-3-amino-6-(methylaminomethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-(methylamino)oxane-3,5-diol,sulfuric acid
D-Streptamine, O-2-amino-2,3,4,6-tetradeoxy-6-(methylamino)-a-D-erythro-hexopyranosyl-(14)-O-[3-deoxy-4-C-methyl-3-(methylamino)-b-L-arabinopyranosyl-(16)]-2-deoxy-, sulfate (salt) (9CI) | [EINECS(EC#)]
1308068-626-2 | [Molecular Formula]
C20H43N5O11S | [MDL Number]
MFCD00941451 | [MOL File]
66803-19-8.mol | [Molecular Weight]
561.65 |
| Chemical Properties | Back Directory | [Melting point ]
>205°C (dec.) | [Boiling point ]
667℃ | [RTECS ]
WK2196000 | [Fp ]
>110°(230°F) | [storage temp. ]
Hygroscopic, Refrigerator, under inert atmosphere | [solubility ]
DMSO (Very Slightly, Heated, Sonicated), Water (Slightly) | [form ]
Solid | [color ]
White to Pale Yellow | [Water Solubility ]
Freely soluble in water | [Stability:]
Hygroscopic |
| Hazard Information | Back Directory | [Uses]
Micronomicin Sulfate is an aminoglycoside antibiotic with neuromuscular blocking activity. | [Definition]
ChEBI: Micronomicin sulfate is an aminoglycoside sulfate salt. It is functionally related to a micronomicin. | [in vivo]
Micronomicin sulfate is highly active against various bacterial infections in mice, and has an intravenous acute LD50 in mice of 93 mg/kg[1].Micronomicin sulfate (intravenous injection; 4-100 mg/kg; 30 days) is injected for subacute toxicity study. The wistar rats dies at the dose level of 100 mg/kg (10 out of 30 animals): renal disorders and ataxia. The renal histological disorders occurrs mainly at the dose levels of 25 mg/kg and over[3]. | Animal Model: | Wistar rats[3] | | Dosage: | 4, 10, 25, 63 mg/kg and 100 mg/kg | | Administration: | Intravenous injection; 30 days | | Result: | Led to death of rat at 100 mg/kg. |
| [IC 50]
Aminoglycoside |
|
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