| Identification | Back Directory | [Name]
DESTRUXIN A | [CAS]
6686-70-0 | [Synonyms]
DESTRUXIN A
destruxin A from metarhizium anisopliae
Destruxin A from Metarrhizium anisopliae
Destruxin A, 98%, from Metarhizium anisopliae
Destruxin A from Metarrhizium anisopliae >=98% (HPLC)
3-Ethenylcyclo(D-Lac-L-Pro-L-Ile-N-methyl-L-Val-N-methyl-L-Ala-βAla-)
Cyclo[N-methyl-L-alanyl-β-alanyl-(2R)-2-hydroxy-4-pentenoyl-L-prolyl-L-isoleucyl-N-methyl-L-valyl]
N-[N-[(R)-2-Hydroxy-1-oxo-4-pentenyl]-L-Pro-L-Ile-N-methyl-L-Val-N-methyl-L-Ala-]-β-alanine lactone
N-[N-[(2R)-1-Oxo-2-hydroxy-4-pentenyl]-L-Pro-L-Ile-N-methyl-L-Val-N-methyl-L-Ala-]-β-alanine lactone | [Molecular Formula]
C29H47N5O7 | [MDL Number]
MFCD01736100 | [MOL File]
6686-70-0.mol | [Molecular Weight]
577.71 |
| Chemical Properties | Back Directory | [Melting point ]
188-189 °C | [Boiling point ]
875.6±65.0 °C(Predicted) | [density ]
1.18±0.1 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
Acetonitrile: Soluble; DMF: Soluble; DMSO: Soluble | [form ]
A powder | [pka]
13.53±0.70(Predicted) | [color ]
White to off-white | [biological source]
Metarrhizium anisopliae |
| Hazard Information | Back Directory | [Uses]
Destruxin A from Metarrhizium anisopliae has been used for immersion and inoculation bioassay in Rhipicephalus (Boophilus) microplus. It has been used as a transport inhibitor in Drosophila melanogaster. | [Biochem/physiol Actions]
Destruxin A is a cyclic hexadepsipeptide produced by fungus causing paralysis and death in insects. May suppress the insect immune response. Possesses an inhibitory activity on leukemic cell proliferation, decreasing the number of cells in G2/M phase. It is virustatic against arboviruses. | [in vivo]
Destruxin A (injection; 86 μM; single dose) can specifically inhibit the humoral immune response of Drosophila melanogaster, making the flies more susceptible to bacterial infections[3]. | [storage]
Store at -20°C |
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