| Identification | Back Directory | [Name]
Methanone, [4-[4-[[(2,4-dichlorophenyl)methyl]amino]pyrido[2,3-d]pyrimidin-2-yl]-1-piperazinyl](2R)-2-piperidinyl- | [CAS]
668980-17-4 | [Synonyms]
CCR4 antagonist 4
Methanone, [4-[4-[[(2,4-dichlorophenyl)methyl]amino]pyrido[2,3-d]pyrimidin-2-yl]-1-piperazinyl](2R)-2-piperidinyl- | [Molecular Formula]
C24H27Cl2N7O | [MOL File]
668980-17-4.mol | [Molecular Weight]
500.42 |
| Chemical Properties | Back Directory | [Boiling point ]
733.5±70.0 °C(Predicted) | [density ]
1.388±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
9.13±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
CCR4 antagonist 4 (compound 22) is a selective and potent antagonist of the CC chemokine receptor-4 (CCR4), with an IC50 of 0.02 μM. CCR4 antagonist 4 also blocks MDC-mediated chemotaxis (IC50: 0.007 μM) and Ca2+ mobilization (IC50: 0.003 μM). CCR4 antagonist 4 can be used for allergic inflammation research[1]. | [IC 50]
CCR4: 0.02 μM (IC50) | [References]
[1] Purandare AV, et al. Core exploration in optimization of chemokine receptor CCR4 antagonists. Bioorg Med Chem Lett. 2007 Feb 1;17(3):679-82. DOI:10.1016/j.bmcl.2006.10.091 |
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