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669749-45-5

669749-45-5 Structure

669749-45-5 Structure
IdentificationBack Directory
[Name]

2-[(6-methoxy-4-methylquinazolin-2-yl)amino]-6-{[(1-phenyl-1H-tetrazol-5-yl)sulfanyl]methyl}pyrimidin-4(3H)-one
[CAS]

669749-45-5
[Synonyms]

DCE42
DCE-42
DCE 42
DCE_42
2-[(6-methoxy-4-methylquinazolin-2-yl)amino]-6-{[(1-phenyl-1H-tetrazol-5-yl)sulfanyl]methyl}pyrimidin-4(3H)-one
[Molecular Formula]

C22H19N9O2S
[MOL File]

669749-45-5.mol
[Molecular Weight]

473.51
Chemical PropertiesBack Directory
[Boiling point ]

769.5±70.0 °C(Predicted)
[density ]

1.53±0.1 g/cm3(Predicted)
[pka]

6.83±0.50(Predicted)
Hazard InformationBack Directory
[Description]

DCE_42 is a novel EZH2 inhibitor that also displays significant anti-proliferation activity against lymphoma cell lines.
[Uses]

DCE_42 is a potent EZH2 inhibitor with an IC50 value of 22.6 μM. DCE_42 inhibits cell proliferation and has the potential for the research of lymphoma[1].
[IC 50]

EZH2: 22.6 μM (IC50)
[References]

[1] Wu Y, et al. Identification of novel EZH2 inhibitors through pharmacophore-based virtual screening and biological assays. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3813-7. DOI:10.1016/j.bmcl.2016.05.018
669749-45-5 suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
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Company Name: TargetMol Chemicals Inc.
Tel: +17819995354 , +17819995354
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Tel: 15002134094
Website: https://www.targetmol.cn/
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