| Identification | Back Directory | [Name]
Acetamide, N-[(3R)-1-[(6-fluoro-2-naphthalenyl)methyl]-3-pyrrolidinyl]-2-[1-[(3-methyl-1-oxido-2-pyridinyl)carbonyl]-4-piperidinylidene]- | [CAS]
671204-98-1 | [Synonyms]
Acetamide, N-[(3R)-1-[(6-fluoro-2-naphthalenyl)methyl]-3-pyrrolidinyl]-2-[1-[(3-methyl-1-oxido-2-pyridinyl)carbonyl]-4-piperidinylidene]- | [Molecular Formula]
C29H31FN4O3 | [MOL File]
671204-98-1.mol | [Molecular Weight]
502.58 |
| Hazard Information | Back Directory | [Uses]
YM-344031 is an orally active antagonist for CCR3. YM-344031 inhibits binding of Eotaxin-1 and RANTES to CCR3, with IC50 of 3.0 and 16.3 nM. YM-344031 inhibits ligand-induced rise in intracellular Ca[2+] and the ligand-induced chemotaxis. YM-344031 inhibits eotaxin-1-induced changes in eosinophil morphology in macaques blood, and prevents allergic skin reactions in a mouse allergy model[1]. | [IC 50]
CCR3 | [References]
[1] Suzuki K, et al., In vitro and in vivo characterization of a novel CCR3 antagonist, YM-344031. Biochem Biophys Res Commun. 2006 Jan 27;339(4):1217-23. DOI:10.1016/j.bbrc.2005.11.141 |
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