| Identification | Back Directory | [Name]
3-MORPHOLIN-4-YLMETHYLBENZOIC ACID | [CAS]
67451-81-4 | [Synonyms]
AKOS BB-9413
3-(Morpholinomethyl)
3-(Morpholinomethyl)benzoic Acid
3-MORPHOLIN-4-YLMETHYLBENZOIC ACID
3-(4-Morpholinylmethyl)Benzoic acid
3-Morpholin-4-ylmethylbenzoicacid95%
3-MORPHOLIN-4-YLMETHYLBENZOIC ACID 95%
Benzoic acid, 3-(4-morpholinylmethyl)- | [Molecular Formula]
C12H15NO3 | [MDL Number]
MFCD05841588 | [MOL File]
67451-81-4.mol | [Molecular Weight]
221.25 |
| Chemical Properties | Back Directory | [Boiling point ]
376.9±32.0 °C(Predicted) | [density ]
1.233±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [pka]
3.98±0.10(Predicted) | [Appearance]
White to off-white Solid |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 3-morpholin-4-ylmethylbenzoic acid from methyl 3-(4-morpholinylmethyl)benzoate: to a solution of methyl 3-(4-morpholinylmethyl)benzoate (5.02 g, 21.0 mmol) in methanol (100 mL) was added a sodium hydroxide solution (21.0 mL, 42.0 mmol, 2M). The reaction mixture was heated at 50 °C with stirring for 16 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was adjusted to pH=3 with 1M hydrochloric acid and the resulting suspension was subsequently filtered. The collected solid was dissolved in acetonitrile (15 mL) and concentrated to afford 3-(morpholin-4-ylmethyl)benzoic acid (4.6 g, 100% yield) as a white solid, which was used directly in the subsequent reaction without further purification. | [References]
[1] Patent: WO2018/169777, 2018, A1. Location in patent: Paragraph 0229 |
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Cool Pharm, Ltd
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Henan Alfachem Co.,Ltd.
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