| Identification | Back Directory | [Name]
Alclometasone | [CAS]
67452-97-5 | [Synonyms]
Vaderm
Alclometasone
AlcloMethasone
ALCLOMETHASONE DIPROPIONATE
7α-Chloro-16α-methylprednisolone
7α-Chloro-16α-methyl Prednisolone
7α-Chloro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione
(7α,11β,16α)-7-Chloro-11,17,21-trihydroxy-16-Methylpregna-1,4-diene-3,20-dione
Pregna-1,4-diene-3,20-dione, 7-chloro-11,17,21-trihydroxy-16-methyl-, (7α,11β,16α)- | [Molecular Formula]
C22H29ClO5 | [MDL Number]
MFCD05662214 | [MOL File]
67452-97-5.mol | [Molecular Weight]
408.92 |
| Chemical Properties | Back Directory | [Melting point ]
176-179° | [alpha ]
D26 +47.5° (c = 0.3 in DMF) | [Boiling point ]
607.1±55.0 °C(Predicted) | [density ]
1.34±0.1 g/cm3(Predicted) | [pka]
12.30±0.70(Predicted) |
| Hazard Information | Back Directory | [Uses]
A metabolite of Alclometasone dipropionate (A514580); a synthetic glucocorticoid steroid for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasocons
trictive agent. | [Uses]
As a metabolite of Alclometasone dipropionate; Alclometasone can be used as a synthetic glucocorticoid steroid for topical use in dermatology as anti-inflammatory, antipruritic, antiallergic, antiproliferative and vasoconstrictive agent.
| [Definition]
ChEBI: A prednisolone compound having an alpha-chloro substituent at the 7-position and an alpha-methyl substituent at the 16-position. | [Brand name]
Aclovate
(GlaxoSmithKline). | [in vivo]
The prodrug of alclometasone is alclometasone dipropionate[2].Alclometasone dipropionate (subcutaneous injection; 1 % (w/v) arabic gum; 2 weeks) inhibits the activity of androgen-dependent cytochrome P450 and O-depropylation activity as a dose-dependent manner in male Slc-Wistar strain rats. However, it has no effects on hepatic drug metabolism in female rats or DS strain mice[2]. |
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