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67469-57-2

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67469-57-2 Structure

67469-57-2 Structure
IdentificationBack Directory
[Name]

1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDE
[CAS]

67469-57-2
[Synonyms]

CS-1338
GBR 12921
GBR-12783
GBR127832HCl
GBR 12783 DIHYDROCHLORIDE
1-(2-(Benzhydryloxy)ethyl)-4-cinnamylpiperazine
1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenyl-2-propenyl)piperazine
Piperazine,1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-2-propenyl)-
1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenyl-2-propen-1-yl)piperazine
Piperazine, 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-2-propen-1-yl)-
1-(2-DIPHENYLMETHOXYETHYL)-4-(3-PHENYL-2-PROPENYL)-PIPERAZINE DIHYDROCHLORIDE
1-[2-(diphenylMethoxy)ethyl]-4-(3-phenylprop-2-en-1-yl)piperazine dihydrochloride
[Molecular Formula]

C28H32N2O
[MDL Number]

MFCD12828854
[MOL File]

67469-57-2.mol
[Molecular Weight]

412.57
Chemical PropertiesBack Directory
[Melting point ]

>200°C (dec.)
[Boiling point ]

551℃
[density ]

1.085
[Fp ]

148℃
[storage temp. ]

Desiccate at -20°C
[solubility ]

Methanol (Slightly), Water (Slightly, Heated)
[form ]

Solid
[color ]

White to Off-White
Hazard InformationBack Directory
[Chemical Properties]

White to off-white powder
[Uses]

GBR 12783 is a very potent and selective inhibitor of dopamine uptake.
[Definition]

ChEBI: 1-[2-(diphenylmethyl)oxyethyl]-4-(3-phenylprop-2-enyl)piperazine is a diarylmethane.
[Biological Activity]

A very potent and selective inhibitor of dopamine uptake (IC 50 for inhibition of [ 3 H]-dopamine uptake in rat striatal synaptosomes is 1.8 nM).
[in vivo]

GBR 12783 (10 mg/kg; intraperitoneal injection; for 100 minutes; male Sprague-Dawley rats) treatment reinforces specifically dopamine transmission only at synapses instantaneously active, increases hippocampal ACh release and improves memory performance in a passive avoidance task[1].

Animal Model:Male Sprague-Dawley rats (180-200 g)[1]
Dosage:10 mg/kg
Administration: Intraperitoneal injection; for 100 minutes
Result:For a moderate electric shock intensity (0.4 mA), improveed retention performance, increased hippocampal acetylcholine release in vivo.
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