| Identification | Back Directory | [Name]
GBR 12783 dihydrochloride | [CAS]
67469-75-4 | [Synonyms]
GBR 12921 dihydrochloride
Piperazine,1-[2-(diphenylmethoxy)ethyl]-4-(3-phenyl-2-propenyl)-,dihydrochloride | [Molecular Formula]
C28H33ClN2O | [MOL File]
67469-75-4.mol | [Molecular Weight]
449.04 |
| Chemical Properties | Back Directory | [storage temp. ]
Desiccate at -20°C | [solubility ]
Water:4.86(Max Conc. mg/mL);10.01(Max Conc. mM) | [form ]
Powder | [color ]
White to off-white | [Water Solubility ]
Soluble to 10 mM in water with gentle warming |
| Hazard Information | Back Directory | [Uses]
GBR 12783 Dihydrochloride is a potent, selective dopamine uptake inhibitor. | [in vivo]
GBR 12783 (10 mg/kg; intraperitoneal injection; for 100 minutes; male Sprague-Dawley rats) treatment reinforces specifically dopamine transmission only at synapses instantaneously active, increases hippocampal ACh release and improves memory performance in a passive avoidance task[1]. | Animal Model: | Male Sprague-Dawley rats (180-200 g)[1] | | Dosage: | 10 mg/kg | | Administration: | Intraperitoneal injection; for 100 minutes | | Result: | For a moderate electric shock intensity (0.4 mA), improveed retention performance, increased hippocampal acetylcholine release in vivo.
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| [storage]
Desiccate at -20°C |
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| Company Name: |
BOC Sciences
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| Tel: |
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| Website: |
https://www.bocsci.com |
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