| Identification | Back Directory | [Name]
4H-1-Benzopyran-4-one, 2,3-dihydro-3-[(3-hydroxy-4-methoxyphenyl)methyl]-7-methoxy- | [CAS]
674786-37-9 | [Synonyms]
DeoxB7
Deox-B-7
Deox B 7
Deox B 7,4
4 dimethyl ether
Deoxysappanone B 7
Deoxysappanone-B-7
Deoxysappanone B 7,4 dimethyl ether
Deoxysappanone-B-7,4 dimethyl ether
4H-1-Benzopyran-4-one, 2,3-dihydro-3-[(3-hydroxy-4-methoxyphenyl)methyl]-7-methoxy- | [Molecular Formula]
C18H18O5 | [MOL File]
674786-37-9.mol | [Molecular Weight]
314.33 |
| Hazard Information | Back Directory | [Description]
Deox B 7,4 is a reversible microtubule inhibitor. It acts by increasing lysosomal V-ATPase activity and lysosome acidity. | [Uses]
(Rac)-Deox B 7,4, a homoisoflavanoid compound, inhibits microtubule polymerization via binding near the colchicine site and promote reversible G2 arrest. (Rac)-Deox B 7,4 possesses nanomolar anti-leukemic activity[1]. | [References]
[1] Dannie Bernard, et al. Select microtubule inhibitors increase lysosome acidity and promote lysosomal disruption in acute myeloid leukemia (AML) cells. Apoptosis. 2015 Jul;20(7):948-59. DOI:10.1007/s10495-015-1123-3 |
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