| Identification | Back Directory | [Name]
Ethanol, 2,2'-[[4-[4-(phenoxymethyl)phenyl]butyl]imino]bis- | [CAS]
675132-92-0 | [Synonyms]
Ethanol, 2,2'-[[4-[4-(phenoxymethyl)phenyl]butyl]imino]bis- | [Molecular Formula]
C21H29NO3 | [MOL File]
675132-92-0.mol | [Molecular Weight]
343.46 |
| Hazard Information | Back Directory | [Description]
Oe-9000 is a novel blocker of voltage-gated Na(+) currents in neurons. It reversibly reduces slowly activating and inactivating tetrodotoxin-resistant (TTX-R) Na(+) currents as well as rapidly activating and inactivating TTX-sensitive (TTX-S) Na(+) currents at low micromolar concentrations. | [Uses]
Oe-9000 is a compound with local anesthetic activity that inhibits voltage-gated Na+ currents in neurons, including both TTX-resistant and TTX-sensitive currents, with effects superior to those of some other local anesthetics. | [References]
[1] Blockade of TTX-resistant and TTX-sensitive Na+ currents in cultured dorsal root ganglion neurons by fomocaine and the fomocaine derivative Oe 9000 DOI:10.1016/j.brainres.2010.08.033 |
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