| Identification | Back Directory | [Name]
CALCIUM TITRIPLEX(R), DIHYDRATE | [CAS]
6766-87-6 | [Synonyms]
PhEur,BP,USP
Calciumtitriplexdihydrate
Calcium disodium edta dihydrate
ETHYLENDIAMINTETRAACETIC CALCIUM DISODIU | [Molecular Formula]
C10H16CaN2Na2O10 | [MDL Number]
MFCD04112745 | [MOL File]
6766-87-6.mol | [Molecular Weight]
410.3 |
| Chemical Properties | Back Directory | [solubility ]
Methanol (Slightly), Water (Slightly) | [form ]
Solid | [color ]
White to Off-White | [Stability:]
Stable under recommended storage conditions., Stable Under Recommended Storage C |
| Hazard Information | Back Directory | [Uses]
CaⅡ-EDTA disodium dihydrate (Calcium disodium EDTA dihydrate) is an orally active metal chelating reagent, exhibits bactericidal activities against periodontal pathogens Aggregatibacter actinomycetemcomitans, Prevotella intermedia and Porphyromonas gingivalis[1]. CaⅡ-EDTA disodium dihydrate is effective chelating antidotes for lead- and cadmium poisoning[2][3]. | [in vivo]
CaⅡ-EDTA disodium dehydrate (50 mg/kg, p.o. for 4 weeks) alleviates the toxic effects of cadmium on kidney and bone with preference to the nanoparticles form[2]. | Animal Model: | Sprague Dawley rats [2] | | Dosage: | 50 mg/kg/day | | Administration: | p.o. for 4 weeks (three-day break after each four consecutive days of administration) | | Result: | Increased the body weight compared to the Cd-intoxicated group.
Decreased in serum creatinine and cadmium concentration compared to the Cd-intoxicated group.
Showed a good radio-density of the skeleton.
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| [References]
[1] Miura, T. et al., Ca (II)-EDTA shows antimicrobial activity against periodontopathic bacteria. Journal of Biomedical Science and Engineering, 5, 10-14.
[2] Saleh SM, et al., Do Nanoparticles of Calcium Disodium EDTA Minimize the Toxic Effects of Cadmium in Female Rats? Biol Trace Elem Res. 2023 Sep 18. DOI:10.1007/s12011-023-03842-6
[3] Saxena G, et al., Lead-induced oxidative stress and hematological alterations and their response to combined administration of calcium disodium EDTA with a thiol chelator in rats. J Biochem Mol Toxicol. 2004;18(4):221-33. DOI:10.1002/jbt.20027 |
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| Company Name: |
Merck Millipore
|
| Tel: |
1-400-889-1988 400-889-1988 |
| Website: |
http://www.merckmillipore.com |
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