| Identification | Back Directory | [Name]
9H-Fluoren-2-aMine, 7-broMo-N,N-diMethyl- | [CAS]
677746-25-7 | [Synonyms]
K162
K 01-162
9H-Fluoren-2-aMine, 7-broMo-N,N-diMethyl- | [Molecular Formula]
C15H14BrN | [MOL File]
677746-25-7.mol | [Molecular Weight]
288.18 |
| Chemical Properties | Back Directory | [Boiling point ]
418.5±38.0 °C(Predicted) | [density ]
1.423±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : 14.29 mg/mL (49.59 mM) | [form ]
Solid | [pka]
4.73±0.20(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
K 01-162 (K162) inhibits the fibril formation of Aβ peptides and eliminates their neurotoxicity. K 01-162 binds with Aβ42 peptide with an EC50 value of 80 nM. K 01-162 binds directly to AβO with a KD value of 19 μM. K 01-162 is capable of penetrating the brain and can be used for the research of Alzheimer’s disease[1][2]. | [in vivo]
K 01-162 (100 μM; intracerebroventricular infusion 0.25 μL/h for 2 weeks) attenuates amyloid load in vivo[2]. | Animal Model: | 5xFAD mice with cerebral Aβ amyloidosis[2] | | Dosage: | 100 μM | | Administration: | Intracerebroventricular infusion; 100 μM 0.25 μL/h; for 2 weeks | | Result: | Caused no apparent toxicity and significantly reduced the amyloid load in hippocampus to
50% of the mock-treated level. |
| [storage]
Store at -20°C | [References]
[1] Li J, et al. Alzheimer's disease drug candidates stabilize A-β protein native structure by interacting with the hydrophobic core. Biophys J. 2011 Feb 16;100(4):1076-82. DOI:10.1016/j.bpj.2010.12.3741
[2] Hong HS, et al. Candidate anti-A beta fluorene compounds selected from analogs of amyloid imaging agents. Neurobiol Aging. 2010 Oct;31(10):1690-9. DOI:10.1016/j.neurobiolaging.2008.09.019 |
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| Company Name: |
Musechem
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+1-800-259-7612 |
| Website: |
www.musechem.com |
| Company Name: |
MedChemExpress
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| Tel: |
021-58955995 |
| Website: |
www.medchemexpress.com |
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