| Identification | Back Directory | [Name]
Dendrophenol | [CAS]
67884-30-4 | [Synonyms]
Phenol, 5-[2-(3-hydroxy-5-methoxyphenyl)ethyl]-2-methoxy-
Gigantol ( 5-[2-(3-Hydroxy-5-methoxyphenyl)ethyl]-2-methoxyphenol) | [Molecular Formula]
C16H18O4 | [MDL Number]
MFCD11100326 | [MOL File]
67884-30-4.mol | [Molecular Weight]
274.31 |
| Chemical Properties | Back Directory | [Boiling point ]
454.1±40.0 °C(Predicted) | [density ]
1.204±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMSO : ≥ 160 mg/mL (583.28 mM) | [form ]
Solid | [pka]
9.63±0.10(Predicted) | [color ]
White to off-white | [InChI]
InChI=1S/C16H18O4/c1-19-14-8-12(7-13(17)10-14)4-3-11-5-6-16(20-2)15(18)9-11/h5-10,17-18H,3-4H2,1-2H3 | [InChIKey]
SDXKZPQOVUDXIY-UHFFFAOYSA-N | [SMILES]
C1(O)=CC(CCC2=CC(OC)=CC(O)=C2)=CC=C1OC |
| Hazard Information | Back Directory | [Chemical Properties]
Off-white crystals, easily soluble in methanol and ethyl acetate, almost insoluble in water, derived from Dendrobium nobile. | [Uses]
Dendrophenol can be used to protect against high glucose-evoked nephrotoxicity in vivo. It can be used with HPLC-PDA-HRMS-SPE-NMR for determination of its inhibitive activities. | [Biological Activity]
Gigantol is a bibenzyl compound isolated from Dendrobium orchids (Dendrobium aphyllumDendrobium draconisDendrobium aurantiacumetc.) th at exhibits potent cytotoxic activity against several cancer cell lines. It inhibits the migratory behavior of non-small cell lung cancer cells. Gigantol inhibits galactose-induced formation of cataracts through repression of the gene expression and activity of AR and iNOS. | [in vivo]
LDD and Gigantol isomer-1 (25–100 mg/kg, p.o.) significantly increase the hot-plate latency in comparison to vehicle-treated mice and decreased carrageenaninduced inflammation in rats[2]. | [storage]
Store at -20°C |
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