| Identification | Back Directory | [Name]
Dehydroevodiamine | [CAS]
67909-49-3 | [Synonyms]
Dehydroevodiamine
14-Methyl-5(7H)-oxo-8,13-dihydroindolo[2',3':3,4]pyrido[2,1-b]quinazoline-14-ium
5,7,8,13-Tetrahydro-14-methyl-5-oxoindolo[2',3':3,4]pyrido[2,1-b]quinazolin-14-ium
8,13-Dihydro-14-methyl-5-oxoindolo[2',3':3,4]pyrido[2,1-b]quinazolinium inner salt
Indolo[2',3':3,4]pyrido[2,1-b]quinazolinium,8,13-dihydro-14-methyl-5-oxo-, inner salt
14-Methyl-5-oxo-7,8-dihydro-5H-indolo[2',3':3,4]-pyrido[2,1-b]quinazolin-14-ium-13-ide | [EINECS(EC#)]
200-258-5 | [Molecular Formula]
C19H15N3O | [MDL Number]
MFCD11656140 | [MOL File]
67909-49-3.mol | [Molecular Weight]
301.35 |
| Chemical Properties | Back Directory | [Melting point ]
190-192℃ | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
powder | [color ]
Yellow | [InChI]
InChI=1S/C19H15N3O/c1-21-16-9-5-3-7-14(16)19(23)22-11-10-13-12-6-2-4-8-15(12)20-17(13)18(21)22/h2-9H,10-11H2,1H3 | [InChIKey]
VXHNSVKJHXSKKM-UHFFFAOYSA-N | [SMILES]
O=C1C2C=CC=CC=2[N+](C)=C2C3=C(CCN12)C1C=CC=CC=1[N-]3 |
| Hazard Information | Back Directory | [Chemical Properties]
White crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from dried near-ripe fruit of Evodia sclerosus. | [Uses]
Dehydroevodiamine is a novel alkaloid which displays butyrylcholinesterase inhibitory activity in vivo. | [Biological Activity]
Dehydroevodiamine, a quinazoline alkaloid isolated from Evodiae Fructus, has antiarrhythmic effects on guinea pig ventricular myocytes. It inhibits LPS-induced expression of iNOS, COX-2, PGE2 and NF-κB in mouse macrophages. | [Physiological effects]
Dehydroevodiamine has an antihypertensive and antitumor effects. | [in vitro]
Dehydroevodiamine (0-50 μM; 2 hours) inhibits iNOS and COX-2 expression and prevents degradation of IκB-α in LPS induced RAW 264.7 macrophages. Dehydroevodiamine (0-50 μM; 2 hours) inhibits a LPS -induced increase in the iNOS and COX-2 mRNA expression. Western Blot Analysis | Cell Line: td> | RAW 264.7 macrophage cells | | Concentration: | 10 μM, 30 μM, 50 μM | | Incubation Time: | pretreated 2 hours | | Result: | Reduced iNOS and COX-2 expression and increased IκB-α expression. | RT-PCR < td class="col1"> Cell Line: | RAW 264.7 macrophage cells | | Concentration: | 10 μM, 30 μM, 50 μM | td> | Incubation Time: | pretreated 2 hours | | Result: | Reduced iNOS and COX-2 mRNA expression. | | [target]
| Target | Value | NF-κB
() | COX-2
() | iNOS
() | PGE2
() |
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