67927-44-0

19932-85-5

74-88-4

67927-44-0

Example 3: Scheme B2; To a solution of 6-bromobenzo[d]oxazol-2(3H)-one (1 eq., 23 mmol, 5.0 g) in acetone (230 ml) was sequentially added potassium carbonate (1.5 eq., 35 mmol, 5.0 g) and iodomethane (1.2 eq., 28 mmol, 4.0 g); The reaction mixture was stirred for 4 hours at room temperature. After completion of the reaction, the acetone solvent was partially concentrated under reduced pressure; the concentrated mixture was poured into 1N HCl aqueous solution and the precipitate was collected by filtration and washed sequentially with water, isopropanol and isopropyl ether to afford 6-bromo-3-methylbenzo[d]oxazol-2(3H)-one (4.22 g, Yield = 79%, Purity (LC) = 99%) as a pinkish pink powder.