| Identification | Back Directory | [Name]
Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside | [CAS]
68027-15-6 | [Synonyms]
Pulsatilla saponin D, BR
Pulsatilla Saponin D (90%)
Pulsatilla saponin D (SB365)
Pulsatilla saponin D 68027-15-6
Hederagenin 3-O-α-L-rhaMnopyranosyl(1→2)-(β-D-glucopyranosyl(1→4))-α-L-arabinopyranoside
Olean-12-en-28-oic acid,3-[[O-6-deoxy-a-L-mannopyranosyl-(12)-O-[b-D-glucopyranosyl-(14)]-a-L-arabinopyranosyl]oxy]-23-hydroxy-, (3b,4a)-
Olean-12-en-28-oic acid, 3-[[O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-α-L-arabinopyranosyl]oxy]-23-hydroxy-, (3β,4α)- | [EINECS(EC#)]
211-708-6 | [Molecular Formula]
C47H76O17 | [MDL Number]
MFCD28124361 | [MOL File]
68027-15-6.mol | [Molecular Weight]
913.1 |
| Chemical Properties | Back Directory | [Melting point ]
239-241℃ | [Boiling point ]
997.6±65.0 °C(Predicted) | [density ]
1.40±0.1 g/cm3 (20 ºC 760 Torr) | [storage temp. ]
Hygroscopic, -20°C Freezer, Under inert atmosphere | [solubility ]
Methanol (Slightly), Pyridine | [form ]
Solid | [pka]
4.63±0.70(Predicted) | [color ]
White to Light Beige |
| Hazard Information | Back Directory | [Description]
Pulsatilla saponin D is an oleanane-type saponin that has been found in P. koreana and has anticancer activity.1 It is cytotoxic to A549, SKOV3, SK-MEL-2, and HCT15 cells (EC50s = 11.25, 13.17, 3.04, and 11.86 μM, respectively). Pulsatilla saponin D (6 mg/kg per day) reduces tumor volume in a murine Lewis lung carcinoma model. | [Uses]
Pulsatilla Saponin D shows antiangiogenic and antitumor activity. | [Definition]
ChEBI: Pulsatilla saponin D is a triterpenoid. It has a role as a metabolite. | [in vivo]
Pulsatilla saponin D (6.4 mg/kg) exhibits anti-tumor activity in Lewis lung carcinoma model[4]. | Animal Model: | 2x2x2 mm3 tumor fragments of a Lewis lung carcinoma (LLC) transplanted s.c. into the auxiliary region of the BDF1 mice[4]. | | Dosage: | 6.4 mg/kg. | | Administration: | Intraperitoneally on the 1 st to 7 th and 9 th to 14 th day. | | Result: | Had such a potent antitumor effect (IR, 82 %) on a solid tumor, which is higher than Adriamycin (IR, 64%). |
| [References]
[1] SEONG-CHEOL BANG. Antitumor activity of Pulsatilla koreana saponins and their structure-activity relationship.[J]. Chemical & pharmaceutical bulletin, 2005, 53 11: 1451-1454. DOI: 10.1248/cpb.53.1451 |
|
|