| Identification | Back Directory | [Name]
S-(P-NITROBENZYL)GLUTATHIONE | [CAS]
6803-19-6 | [Synonyms]
S-(P-NITROBENZYL)GLUTATHIONE
s-(4-nitrobenzyl)glutathione
Glycine, L-γ-glutamyl-S-[(4-nitrophenyl)methyl]-L-cysteinyl-
(2R)-2-[[(2S)-2-[[2-[[(2S,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)-4-oxanyl]oxy]-1-oxopropyl]amino]-3-methyl-1-oxobutyl]amino]-5-amino-5-oxopentanoic acid | [Molecular Formula]
C17H22N4O8S | [MDL Number]
MFCD00057609 | [MOL File]
6803-19-6.mol | [Molecular Weight]
442.44 |
| Hazard Information | Back Directory | [Uses]
S-(p-Nitrobenzyl)glutathione is a competitive glutathionase inhibitor. S-(p-Nitrobenzyl)glutathione is converted to the corresponding cysteine derivatives by rat kidney microsomes. S-(p-Nitrobenzyl)glutathione can be used for the research of metabolic breakdown of glutathione by the glutathionase system[1][2]. | [Definition]
ChEBI: A glutathione derivative in which the thiol hydrogen of glutathione is replaced by a 4-nitrobenzyl group. | [References]
[1] I García-Sáez, et al. Molecular structure at 1.8 A of mouse liver class pi glutathione S-transferase complexed with S-(p-nitrobenzyl)glutathione and other inhibitors. J Mol Biol. 1994 Apr 1;237(3):298-314. DOI:10.1006/jmbi.1994.1232
[2] T Suga, et al. Studies on mercapturic acids. Participation of glutathionase in the conversion of glutathione derivatives to cysteine derivatives. J Biochem. 1966 Aug;60(2):133-9. DOI:10.1093/oxfordjournals.jbchem.a128411 |
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