| Identification | Back Directory | [Name]
KIGAMICIN C | [CAS]
680571-51-1 | [Synonyms]
KIGAMICIN C
Oxazolo[3,2-b]xantheno[4',3',2':4,5][1,3]benzodioxino[7,6-g]isoquinoline-16,19-dione, 3-[[(2S,5S,6R)-5-[(2,6-dideoxy-3-O-methyl-β-D-arabino-hexopyranosyl)oxy]tetrahydro-6-methyl-2H-pyran-2-yl]oxy]-1,2,3,4,8a,9,11,11a,13,14-decahydro-1,4,17,18-tetrahydroxy-11a-methyl-, (1S,3R,4S,8aR,11aR)- | [Molecular Formula]
C41H47NO16 | [MDL Number]
MFCD09954098 | [MOL File]
680571-51-1.mol | [Molecular Weight]
809.81 |
| Hazard Information | Back Directory | [Uses]
Kigamicin C is a novel antibiotic antiproliferative with novel action. | [Uses]
Kigamicin C was discovered by an anti-austerity strategy, targeting cancer cells' tolerance to starvation. It selectively kills PANC-1 cells (a pancreatic cell line) at concentrations 100 times lower under nutrient starved conditions than in normal conditions. The mechanism of action is proposed to be via blockade of aPKB/Akt activation, caused by the withdrawal of nutrients. It is active in vivo against a human pancreatic cancer xenograft model. Kigamicin C also inhibits the growth of Gram positive bacteria including MRSA, but is not active against Gram negative bacteria. |
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Lynnchem
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Novachemistry
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https://www.novachemistry.com/ |
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