| Identification | Back Directory | [Name]
D-PYR-D-PHE-D-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-GLY-NH2 | [CAS]
68059-94-9 | [Synonyms]
(D-Pyr1,D-Phe2,D-Trp3
pglu(1)-phe(2)-trp(3,6)-lhr
[DGLP1,DPHE2,DTRP3,6]-LH-RH
(D-PYR1,D-PHE2,D-TRP3,6)-LHRH
LHRH, pGlu(1)-Phe(2)-Trp(3,6)-
[D-PGLU1, D-PHE2, D-TRP3,6]-LH-RH
[D-PYROGLU1,D-PHE2,D-TRP3,6]-LH-RH
[D-PYR1, D-PHE2, D-TRP3,6]-LH-RH (HUMAN)
DGLP-DPHE-DTRP-SER-TYR-DTRP-LEU-ARG-PRO-GLY-NH2
D-pglu1,D-phe2,D-trp3,6-luteinizing*hormone relea
D-PYR-D-PHE-D-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-GLY-NH2
D-PGLU1,D-PHE2,D-TRP3,6-LUTEINIZING*HORM ONE RELEASI
(D-PYR1,D-PHE2,D-TRP3,6)-GONADOTROPIN-RELEASING HORMONE
D-PYROGLU-D-PHE-D-TRP-SER-TYR-D-TRP-LEU-ARG-PRO-GLY-NH2
[DGLP1,DPHE2,DTRP3,6]-LUTEINIZING HORMONE-RELEASING HORMONE
(D-PYR1,D-PHE2,D-TRP3,6)-LUTEINIZING HORMONE-RELEASING FACTOR
(D-PYR1,D-PHE2,D-TRP3,6)-LUTEINIZING HORMONE-RELEASING HORMONE
[D-PYR1, D-PHE2, D-TRP3,6]-LUTEINIZING HORMONE-RELEASING HORMONE (HUMAN)
Glycinamide, 5-oxo-D-prolyl-D-phenylalanyl-D-tryptophyl-L-seryl-L-tyrosyl-D-tryptophyl-L-leucyl-L-arginyl-L-prolyl- (9CI) | [Molecular Formula]
C67H84N16O13 | [MDL Number]
MFCD00076582 | [MOL File]
68059-94-9.mol | [Molecular Weight]
1321.48 |
| Hazard Information | Back Directory | [Uses]
[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH is a Luteinizing-hormone-releasing hormone (LHRH) analogue. [D-Glp1,D-Phe2,D-Trp3,6]-LH-RH acts as a GnRH receptor antagonist[1]. | [in vivo]
[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH (1.25 and 2.5 mg, subcutaneous injection, b.i.d, for 7 days) prolongs pregnancy in rats[1].
[D-Glp1,D-Phe2,D-Trp3,6]-LH-RH (250 μg) inhibits ovulation by 100% in rats[2].
| [References]
[1] Rivier C, et al. Effect of the LRF-antagonist [D-pGlu1, D-Phe2, D-Trp3,6]-LRF on pregnancy in the rat. Contraception. 1979 Feb;19(2):185-90. DOI:10.1016/s0010-7824(79)80030-x
[2] Rivier JE, et al. A potent luteinizing hormone releasing factor antagonist in vitro and inhibitor of ovulation in the rat. Life Sci. 1978 Aug 28;23(8):869-76. DOI:10.1016/0024-3205(78)90522-2
[3] Hsueh AJ, et al. Effect on an antagonistic analog of gonadotropin releasing hormone upon ovarian granulosa cell function. Life Sci. 1979 Oct 1;25(14):1223-9. DOI:10.1016/0024-3205(79)90464-8 |
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