| Identification | Back Directory | [Name]
1,4-Benzodioxin-2-carboxamide, 2,3-dihydro-N-[4-(4-pyridinyl)-2-thiazolyl]- | [CAS]
681173-76-2 | [Synonyms]
CID5056270
CID-5056270
CID 5056270
1,4-Benzodioxin-2-carboxamide, 2,3-dihydro-N-[4-(4-pyridinyl)-2-thiazolyl]- | [Molecular Formula]
C17H13N3O3S | [MOL File]
681173-76-2.mol | [Molecular Weight]
339.37 |
| Hazard Information | Back Directory | [Description]
CID-5056270 is an inhibitor of ROCK2 enzymatic activity. | [Uses]
ROCK2-IN-8 (Compound 1) is an orally active ROCK2 inhibitor, with an IC50 of 7.2 nM. ROCK2-IN-8 can be used for the research of aqueous humor outflow in porcine eyes and myosin light chain phosphorylation[1]. | [References]
[1] Feng Y, et al. Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors. J Med Chem. 2008 Nov 13;51(21):6642-5. DOI:10.1021/jm800986w |
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