| Identification | Back Directory | [Name]
6-amino-7-bromo-2,3-dihydro-1H-inden-1-one | [CAS]
681246-49-1 | [Synonyms]
6-Amino-7-bromo-indan-1-one
6-amino-7-bromo-2,3-dihydroinden-1-one
6-amino-7-bromo-2,3-dihydro-1H-inden-1-one
1H-Inden-1-one, 6-amino-7-bromo-2,3-dihydro- | [Molecular Formula]
C9H8BrNO | [MDL Number]
MFCD16249550 | [MOL File]
681246-49-1.mol | [Molecular Weight]
226.07 |
| Chemical Properties | Back Directory | [Boiling point ]
379.7±42.0 °C(Predicted) | [density ]
1.693±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [pka]
1.79±0.20(Predicted) | [Appearance]
Light yellow to yellow Solid |
| Hazard Information | Back Directory | [Synthesis]
6-Amino-1-indanone (2.0516 g, 13.94 mmol) was used as starting material, which was dissolved in a 9:1 CHCl3/DMF solvent mixture (52 mL). Bromine (Br2, 0.71 mL, 13.94 mmol) was added slowly and dropwise under stirring conditions. The reaction mixture was continued to be stirred at room temperature for 1 hour. After completion of the reaction, the precipitate was collected by filtration and the filter cake was dried under vacuum to afford the target compound 6-amino-7-bromo-2,3-dihydro-1H-inden-1-one (2.7127 g, 63% yield). The product was detected by mass spectrometry (ESI(+)) and showed m/e 226,228 (M + H)+; mass spectrometry (ESI(-)) showed m/e 225,227 (M-H)-. 1H NMR (300 MHz, DMSO-d6) δ 7.28 (dt, 1H), 7.17 (d, 1H), 5.87 (br s, 3H), 2.89 ( m, 2H), 2.62 (m, 2H). | [References]
[1] Patent: US2004/167128, 2004, A1. Location in patent: Page 40
[2] Patent: WO2009/10260, 2009, A2. Location in patent: Page/Page column 58
[3] Patent: US2010/273830, 2010, A1. Location in patent: Page/Page column 33 |
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| Company Name: |
SynAsst Chemical.
|
| Telephone: |
021-60343070 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15848/0_EN.htm |
| Company Name: |
Acesys Pharmatech
|
| Telephone: |
18860950986 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList15849/0_EN.htm |
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