| Identification | Back Directory | [Name]
Isoliensinine | [CAS]
6817-41-0 | [Synonyms]
Isoliensinine
(+)-Isoliensinin
(+)-Isoliensinine
Isoliensinine USP/EP/BP
(1R)-1-(4-hydroxy-3-{[(1R)-6-methoxy-1-(4-methoxybenzyl)-2-m...
(1R)-1-[[4-hydroxy-3-[[(1R)-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenyl]methyl]-6-methoxy-2-methyl-3,4-dihydro-1H-isoquinolin-7-ol
(1R)-1,2,3,4-Tetrahydro-1-[[4-hydroxy-3-[[(1R)-1,2,3,4-tetrahydro-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-7-isoquinolinyl]oxy]phenyl]methyl]-6-methoxy-2-methyl-7-isoquinolinol
7-Isoquinolinol, 1,2,3,4-tetrahydro-1-[[4-hydroxy-3-[[(1R)-1,2,3,4-tetrahydro-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-7-isoquinolinyl]oxy]phenyl]methyl]-6-methoxy-2-methyl-, (1R)- | [Molecular Formula]
C37H42N2O6 | [MDL Number]
MFCD11042260 | [MOL File]
6817-41-0.mol | [Molecular Weight]
610.747 |
| Chemical Properties | Back Directory | [Melting point ]
69-71℃ | [Boiling point ]
723.1±60.0 °C(Predicted) | [density ]
1.218 | [storage temp. ]
2-8°C(protect from light) | [solubility ]
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | [form ]
powder | [pka]
9.28±0.45(Predicted) | [color ]
White |
| Hazard Information | Back Directory | [Description]
Tomita and his co-workers have obtained this bisisoquinoline alkaloid from the
embryo of the seeds of Nelumbo nucifera Gaertn. The base has [α]29D + 49.3°
(Me2CO) and - 43.3° (CHC13 ). The hydrochloride tetrahydrate forms colourless
crystals, m.p. l85-6°C (dry); the perchlorate monohydrate has m.p. 200-3°C
(dry); [α]22D - 70° (Me2CO) and the styphnate of the O,O-dimethyl ether, also
crystalline, has m.p. l33-5°C; [α]27D - 81.5° (Me2CO). Three methoxyl, two
hydroxyl and two methylimino groups are present. | [Chemical Properties]
Active ingredients extracted from lotus root bark and bark | [Uses]
(+)-Isoliensinine is an alkaloid which displays activation of AMP-activated kinase and regulation of PPARγ receptors. | [Definition]
ChEBI: Isoliensinine is a member of isoquinolines. | [References]
Tomita et aI., Tetrahedron Lett., 2637,3374 (1964) |
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