| Identification | Back Directory | [Name]
Pirmenol | [CAS]
68252-19-7 | [Synonyms]
Pirmenol (Cl-845)
2-Pyridinemethanol, a-[3-(2,6-dimethyl-1-piperidinyl)propyl]-a-phenyl-, cis-
2-Pyridinemethanol, a-[3-(2,6-dimethyl-1-piperidinyl)propyl]-a-phenyl-, cis-(+-)-
2-Pyridinemethanol, α-[3-[(2R,6S)-2,6-dimethyl-1-piperidinyl]propyl]-α-phenyl-, rel-
2-Pyridinemethanol, a-[3-[(2R,6S)-2,6-dimethyl-1-piperidinyl]propyl]-a-phenyl-, rel- (9CI) | [Molecular Formula]
C22H30N2O | [MDL Number]
MFCD01758678 | [MOL File]
68252-19-7.mol | [Molecular Weight]
338.49 |
| Chemical Properties | Back Directory | [Melting point ]
70-71° | [Boiling point ]
499.6±45.0 °C(Predicted) | [density ]
1.046±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
DMF: 2mg/mL,DMSO: 5mg/mL,Ethanol: 10mg/mL,Ethanol:PBS (pH 7.2) (1:5): 0.16mg/mL | [form ]
A solid | [pka]
12.66±0.29(Predicted) | [color ]
White to v. dark grey | [InChI]
1S/C22H30N2O/c1-18-10-8-11-19(2)24(18)17-9-15-22(25,20-12-4-3-5-13-20)21-14-6-7-16-23-21/h3-7,12-14,16,18-19,25H,8-11,15,17H2,1-2H3/t18-,19+,22? | [InChIKey]
APUDBKTWDCXQJA-QIDMFYOTSA-N | [SMILES]
OC(C1=CC=CC=C1)(C2=NC=CC=C2)CCCN3[C@@H](C)CCC[C@H]3C |
| Hazard Information | Back Directory | [Uses]
Cardiac depressant (anti-arrhythmic). | [Definition]
ChEBI: Pirmenol is a racemate. | [Brand name]
Pirmavar (Parke-Davis). | [Biological Activity]
Pirmenol is an antiarrhythmic agent class Ia th at exhibit long half-life and low toxicities. Pirmenol suppresses premature ventricular contractions in human studies. | [in vivo]
Pirmenol (2.5 and 5 mg/kg, p.o.) is effective against the arrhythmias in conscious, coronary artery ligated dogs[4].
Pirmenol (rats) shows LD50s of 359.9 mg/kg (p.o), 23.6 mg/kg (i.v.)[2].
Pirmenol (mice) shows LD50s of 215.5 mg/kg (p.o), 20.8 mg/kg (i.v.)[2].
| Animal Model: | Conscious, coronary artery ligated dogs[4] | | Dosage: | Oral administration (p.o.) | | Administration: | 2.5 and 5 mg/kg | | Result: | Restored normal sinus rhythm, and showed a long duration of activity, wide safety margin. |
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| Company Name: |
Twochem Co.Ltd.
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| Tel: |
021-58111628 15800915896 |
| Website: |
cn.twochem.com |
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