| Identification | Back Directory | [Name]
PPDA | [CAS]
684283-16-7 | [Synonyms]
PPDA
(2S*,3R*)-1-(Phenanthren-2-carbonyl)piperazine-2,3-dicarboxylicacid
2,3-Piperazinedicarboxylic acid, 1-(2-phenanthrenylcarbonyl)-, (2R,3S)-rel- | [Molecular Formula]
C21H18N2O5 | [MDL Number]
MFCD09037337 | [MOL File]
684283-16-7.mol | [Molecular Weight]
378.38 |
| Chemical Properties | Back Directory | [Melting point ]
223-226 °C (decomp) | [Boiling point ]
730.8±60.0 °C(Predicted) | [density ]
1.437±0.06 g/cm3(Predicted) | [storage temp. ]
Store at +4°C | [solubility ]
Soluble to 50 mM in 2eq. NaOH and to 100 mM in DMSO | [form ]
Powder | [pka]
1.73±0.40(Predicted) | [color ]
White |
| Hazard Information | Back Directory | [Uses]
PPDA is a subtype-selective NMDA receptor antagonist that preferentially binds to NR2C/NR2D containing receptors[1]. | [Definition]
ChEBI: (2S,3R)-PPDA is a 1-(phenanthren-2-ylcarbonyl)piperazine-2,3-dicarboxylic acid that has 2S,3R-configuration. It has a role as a NMDA receptor antagonist. It is an enantiomer of a (2R,3S)-PPDA. | [storage]
+4°C | [References]
[1] Kinarsky L, et al. Identification of subunit- and antagonist-specific amino acid residues in the N-Methyl-D-aspartate receptor glutamate-binding pocket. J Pharmacol Exp Ther. 2005 Jun;313(3):1066-74. DOI:10.1124/jpet.104.082990 |
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