| Identification | Back Directory | [Name]
EF 1502 racemic | [CAS]
684645-54-3 | [Synonyms]
EF1502
EF-1502
EF 1502
S)-EF 1502
Rac-EF 1502
(R,S)-EF 1502
EF 1502 racemic
EF1502 free base | [Molecular Formula]
C22H26N2O2S2 | [MOL File]
684645-54-3.mol | [Molecular Weight]
414.58 |
| Hazard Information | Back Directory | [Description]
EF1502 is a potent and selective GABA transporter inhibitor. EF1502 exhibit mechanistic differences in their ability to modulate the ataxia and anticonvulsant action of the extrasynaptic GABA(A) receptor agonist gaboxadol. | [Uses]
EF-1502 is a potent and selective GABA transporter inhibitor with GAT1 and BGT1 inhibitory activity. EF-1502 produces a synergistic anti-epileptic effect when used in combination with Tiagabine (HY-B0696), a compound used to suppress epileptic seizures. The dosing combination of EF-1502 exhibited reduced anti-epileptic efficacy and dyskinesia when used with THIP (HY-10232). The mechanism of EF-1502 differs significantly from Tiagabine, suggesting a unique role in the inhibitory strategy[1]. | [References]
[1] Selective GABA transporter inhibitors tiagabine and EF1502 exhibit mechanistic differences in their ability to modulate the ataxia and anticonvulsant action of the extrasynaptic GABA(A) receptor agonist gaboxadol DOI:10.1124/jpet.111.179671 |
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