| Identification | Back Directory | [Name]
OXANTEL PAMOATE | [CAS]
68813-55-8 | [Synonyms]
OXANTEL PAMOATE
Oxantel Ebonate
Einecs 272-332-6
Octahydronaphthol
Parasite,inhibit,Inhibitor,Oxantel Pamoate,Oxantel
4,4'-Methylenebis[3-hydroxy-2-naphthalenecarboxylic Acid 3-[(1E)-2-(1,4,5,6-Tetrahydro-1-Methyl-2-pyriMidinyl)ethenyl]phenol
1-methyl-2-(3-hydroxyphenylethenyl)-1,4,5,6-tetrahydropyrimidine compound with 4,4'-methylenebis(3-hydroxy-2-naphthoic acid)
1-METHYL-2-[3-HYDROXYPHENYLETHENYL]-1,4,5,6-TETRAHYDROPYRIMIDINE COMPOUND WITH 4,4'-METHYLENEBIS[3-HYDROXY-2-NAPHTHOIC ACID]
(E)-3-[2-(1,4,5,6-Tetrahydro-1-Methyl-2-pyriMidinyl)ethenyl]phenol 4,4'-Methylenebis[3-hydroxy-2-naphthalenecarboxylate] Salt
4,4'-methylenebis[3-hydroxy-2-naphthoic] acid, compound with (E)-3-[2-(1,4,5,6-tetrahydro-1-methylpyrimidin-2-yl)vinyl]phenol (1:1)
4,4'-Methylenebis(3-hydroxy-2-naphthoic) acid, compound with (E)-3-(2-(1,4,5,6-tetrahydro-1-methylpyrimidin-2-yl)vinyl)phenol (1:1)
Phenol, 3-(2-(1,4,5,6-tetrahydro-1-methyl-2-pyrimidinyl)ethenyl), (E)-, 4,4'-methylenebis(3-hydroxy-2-naphthalenecarboxylate) (1:1) (salt)
2-Naphthalenecarboxylic acid, 4,4-methylenebis3-hydroxy-, compd. with 3-(1E)-2-(1,4,5,6-tetrahydro-1-methyl-2-pyrimidinyl)ethenylphenol (1:1)
4-[(3-carboxy-2-hydroxynaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylic acid,3-[(E)-2-(1-methyl-5,6-dihydro-4H-pyrimidin-2-yl)ethenyl]phenol | [EINECS(EC#)]
272-332-6 | [Molecular Formula]
C49H48N4O8 | [MDL Number]
MFCD00079198 | [MOL File]
68813-55-8.mol | [Molecular Weight]
820.93 |
| Chemical Properties | Back Directory | [Melting point ]
>224°C (dec.) | [storage temp. ]
Amber Vial, Refrigerator, Under inert atmosphere | [solubility ]
DMSO (Slightly, Heated), Methanol (Slightly, Heated) | [form ]
neat | [color ]
White to Off-White | [Major Application]
forensics and toxicology
pharmaceutical (small molecule)
veterinary | [InChIKey]
WSYDAPQDBDVYIO-QEFJDTIGSA-N | [SMILES]
CN1CCCN=C1\C=C\c2cccc(O)c2.OC(=O)c3cc4ccccc4c(Cc5c(O)c(cc6ccccc56)C(O)=O)c3O |
| Hazard Information | Back Directory | [Uses]
antiemetic, dopamine antagonist | [Uses]
Oxantel Pamoate is used as an anthelmintic drug. | [Definition]
ChEBI: Oxantel pamoate is a naphthoic acid. | [Brand name]
Telopar (Pfizer). | [in vivo]
The activity of the veterinary drug Oxantel pamoate is studied against Trichuris muris, Ancylostoma ceylanicum and Necator americanus. An ED50s of 4.7 mg/kg is calculated for Oxantel pamoate against T. muris in mice. Combinations of Oxantel pamoate with pyrantel pamoate behaved antagonistically (combination index (CI)=2.53). Oxantel pamoate combined with Levamisole, Albendazole or Ivermectin using ratios based on their ED50s reveals antagonistic effects (CI=1.27, 1.90 and 1.27, respectively). A highly synergistic effect (CI=0.15) is observed when Oxantel pamoate-mebendazole is administered to T. muris-infected mice. Oxantel pamoate (10 mg/kg) lacks activity against Ancylostoma ceylanicum and Necator americanus[1]. |
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