| Identification | Back Directory | [Name]
4-[[2-[[(2-Cyanophenyl)methyl]thio]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl]benzoic acid | [CAS]
688347-51-5 | [Synonyms]
SPL 334
SPL-334 >=98% (HPLC)
4-[[2-[[(2-Cyanophenyl)methyl]thio]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl]benzoic acid
Benzoic acid, 4-[[2-[[(2-cyanophenyl)methyl]thio]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl]- | [Molecular Formula]
C22H15N3O3S2 | [MOL File]
688347-51-5.mol | [Molecular Weight]
433.5 |
| Chemical Properties | Back Directory | [Boiling point ]
694.0±65.0 °C(Predicted) | [density ]
1.41±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 20mg/mL, clear | [form ]
powder | [pka]
4.21±0.10(Predicted) | [color ]
white to beige | [InChIKey]
UWWSCLNCHCROLL-UHFFFAOYSA-N | [SMILES]
OC(C1=CC=C(CN2C(SCC3=CC=CC=C3C#N)=NC(C=CS4)=C4C2=O)C=C1)=O |
| Hazard Information | Back Directory | [Uses]
SPL 334 is an S-Nitrosoglutathione Reductase inhibitor. | [Biological Activity]
SPL-334 is an inhibitor of S-Nitrosoglutathione reductase (GSNOR)the enzyme responsible for regulating cellular concentrations of S-Nitrosoglutathione (GSNO)which plays a critical role in nitric oxide signaling in the respiratory tract. In a mouse model of allergic airway inflammationSPL-334 reduced airway hyperreactivityand in a bleomycin injury model of interstitial lung diseaseSPL-334 reduced lung inflammation and fibrosis. Studies for treatment of asthmaidiopathic pulmonary fibrosis (IPF)and inflammation are ongoing. | [in vivo]
SPL-334 (0.1-1 mg/kg; Intranasal administration; daily, for 7 d; BALB/c recipient mice with DO11.10 CD4+ Th2 xenograft) causes a reduction in allergic airway inflammation[1]. | Animal Model: | BALB/c recipient mice with DO11.10 CD4+ Th2 xenograft[1] | | Dosage: | 0.1 or 1 mg/kg | | Administration: | Intranasal administration; daily, for 7 days | | Result: | Caused a significant reduction in the influx of lymphocytes and eosinophils into the airways and the level of EPO in the BALF.
Reduced the number of OVA-specific T cells and eosinophils during allergic airway inflammation.
Reduced in peribronchial inflammation and mucus secretion during airway inflammation.
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| Company Name: |
BOC Sciences
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| Tel: |
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| Website: |
https://www.bocsci.com |
| Company Name: |
Energy Chemical
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| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
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| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
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