| Safety Data | Back Directory | [WGK Germany ]
WGK 1 | [Storage Class]
8B - Non-combustible corrosive hazardous materials | [Hazard Classifications]
Eye Irrit. 2
Met. Corr. 1
Skin Irrit. 2 |
| Hazard Information | Back Directory | [Uses]
BC21 (NSC 109268) is a β-catenin/Tcf4 inhibitor with an IC50 of 5 μM. BC21 effectively inhibits the binding of β-catenin to Tcf4-derived peptides and suppresses β-catenin/Tcf4-driven reporter gene activity. BC21 can be utilized in cancer research[1]. | [References]
[1] Tian W, et al. Structure-based discovery of a novel inhibitor targeting the β-catenin/Tcf4 interaction. Biochemistry. 2012 Jan 17;51(2):724-31. DOI:10.1021/bi201428h |
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