| Identification | Back Directory | [Name]
2',5-difluoro-2'-deoxy-1-arabinosyluracil | [CAS]
69123-95-1 | [Synonyms]
2',5-difluoro-2'-deoxy-1-arabinosyluracil
2'-Deoxy-2'-fluoro-5-fluoro-arabinouridine
5-Fluoro-2'-fluoro-2'-deoxy-beta-D-arabinouridine
2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-fluoro-
1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-fluoro-2,4(1H,3H)-pyrimidinedione
2,4(1H,3H)-PYRIMIDINEDIONE,1-(2-DEOXY-2-FLUORO-BETA-D-ARABINOFURANOSYL)-5-FLUORO- | [Molecular Formula]
C9H10F2N2O5 | [MOL File]
69123-95-1.mol | [Molecular Weight]
264.183 |
| Chemical Properties | Back Directory | [Melting point ]
168-170 °C(Solv: chloroform (67-66-3); methanol (67-56-1)) | [density ]
1.69±0.1 g/cm3(Predicted) | [pka]
7.63±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
5-Fluoro-1-((2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione (2',5-difluoro-2'-deoxy-1-arabinosyluracil) is a uridine analogue. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents[1]. | [References]
[1] Connolly GP, et al. Uridine and its nucleotides: biological actions, therapeutic potentials. Trends Pharmacol Sci. 1999 May;20(5):218-25. DOI:10.1016/s0165-6147(99)01298-5 |
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