| Identification | Back Directory | [Name]
DL-CAPROYLCARNITINE CHLORIDE | [CAS]
6920-35-0 | [Synonyms]
Zinc02517065
Hexanoyl-L-carnitine HCl
DL-CAPROYLCARNITINE CHLORIDE
DL-HEXANOYLCARNITINE CHLORIDE
Hexanoyl-DL-carnitine chloride
(+/-)-HEXANOYLCARNITINE CHLORIDE | [Molecular Formula]
C13H26ClNO4 | [MDL Number]
MFCD00151472 | [MOL File]
6920-35-0.mol | [Molecular Weight]
295.8 |
| Chemical Properties | Back Directory | [Melting point ]
156-158°C | [storage temp. ]
−20°C | [solubility ]
Methanol (Slightly), Water (Slightly) | [form ]
Solid | [color ]
White to Off-White | [Water Solubility ]
Soluble to 100 mM in water | [Stability:]
Hygroscopic | [InChI]
1S/C13H26NO4.ClH/c1-5-6-7-8-13(17)18-11(9-12(15)16)10-14(2,3)4;/h11H,5-10H2,1-4H3,(H,15,16);1H | [InChIKey]
AWUOLOICNWRXPY-UHFFFAOYSA-N | [SMILES]
Cl.CCCCCC(=O)OC(CC(O)=O)C[N](C)(C)C |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
22-43 | [Safety Statements ]
36/37 | [WGK Germany ]
2 | [Storage Class]
11 - Combustible Solids | [Hazard Classifications]
Acute Tox. 4 Oral
Skin Sens. 1 |
| Hazard Information | Back Directory | [Uses]
(±)-Hexanoylcarnitine Chloride acts as a potential absorption-enhancing agents when used in drugs that are poorly absorbed, particularly in the gastrointestinal track. | [Biological Activity]
(±)-hexanoylcarnitine chloride is an agonist for cholinergic and a homolog of acetylcarnitine chloride (cat no. b6273).acetylcholine receptor (achr) is an integral membrane protein receptor for acetylcholine. there are two kinds of achrs: nicotinic acetylcholine receptors and muscarinic acetylcholine receptors.(±)-hexanoylcarnitine chloride is a cholinergic agonist and an intermediate in lipid metabolism [1]. in retinal ganglion cells, acetylcarnitine and acetylcholine inhibited gabaergic responses to exogenous gaba and gabaergic inhibitory postsynaptic currents [2].in dogs with coronary ligation, (-)-carnitine chloride (lcc) (300 mg/kg) and acetyl (-)-carnitine chloride (alcc) (300 mg/kg) inhibited the ventricular arrhythmia. also, lcc and alcc improved oxidative phosphorylation rate and the mitochondrial function [1]. in the mouse hot plate test, acetyl-l-carnitine (alcar) (100 mg/kg) exhibited analgesia. while, u-73122 and neomycin (the phospholipase c (plc) inhibitors) blocked the increase of the pain threshold induced by alcar. licl that impairing phosphatidylinositol synthesis antagonized the antinociception in a dose-dependent way. pma and pdbu (pkc activators) blocked the increase of the pain threshold in a dose-dependent way. these results suggested that alcar analgesia required the participation of the plc-ip3 pathway [3]. | [References]
[1]. imai s, matsui k, nakazawa m, et al. anti-arrhythmic effects of (-)-carnitine chloride and its acetyl analogue on canine late ventricular arrhythmia induced by ligation of the coronary artery as related to improvement of mitochondrial function. br j pharmacol, 1984, 82(2): 533-542.
[2]. b?hring r, standhardt h, martelli ea, et al. gaba-activated chloride currents of postnatal mouse retinal ganglion cells are blocked by acetylcholine and acetylcarnitine: how specific are ion channels in immature neurons? eur j neurosci, 1994, 6(7): 1089-1099.
[3]. galeotti n, bartolini a, calvani m, et al. acetyl-l-carnitine requires phospholipase c-ip3 pathway activation to induce antinociception. neuropharmacology, 2004, 47(2): 286-294. |
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| Company Name: |
Bide Pharmatech Ltd.
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| Telephone: |
400-1647117 13681763483 |
| Website: |
https://www.bidepharm.com/ |
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