| Identification | Back Directory | [Name]
AZD0424 | [CAS]
692054-06-1 | [Synonyms]
AZD0424
AZD0424,AZD-0424
Ethanone, 1-[4-[2-[[4-[(6-chloro-1,3-dioxolo[4,5-b]pyridin-7-yl)amino]-5-(1-methylethoxy)-7-quinazolinyl]oxy]ethyl]-1-piperazinyl]- | [Molecular Formula]
C25H29ClN6O5 | [MDL Number]
MFCD32201036 | [MOL File]
692054-06-1.mol | [Molecular Weight]
528.99 |
| Hazard Information | Back Directory | [Uses]
AZD0424 is an orally active, and dual selective Src/Abl kinase inhibitor with potential antineoplastic activity[1]. AZD0424 induces apoptosis and cell cycle arrest in lymphoma cells[2]. | [References]
[1] Woodcock VK, et al. A first-in-human phase I study to determine the maximum tolerated dose of the oral Src/ABL inhibitor AZD0424. Br J Cancer. 2018 Mar 20;118(6):770-776. DOI:10.1038/bjc.2017.484
[2] Nowak D, et al. Src kinase inhibitors induce apoptosis and mediate cell cycle arrest in lymphoma cells. Anticancer Drugs. 2007 Oct;18(9):981-95. DOI:10.1097/CAD.0b013e3281721ff6 |
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