| Identification | Back Directory | [Name]
6-Maleimidocaproic acid-PFP ester | [CAS]
692739-25-6 | [Synonyms]
6-Maleimidocaproic acid-PFP ester
6-maleimidohexanoic acid pentafluorophenyl ester
Perfluorophenyl 6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanoate
1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo-, pentafluorophenylester
1H-Pyrrole-1-hexanoic acid, 2,5-dihydro-2,5-dioxo-, 2,3,4,5,6-pentafluorophenyl ester | [Molecular Formula]
C16H12F5NO4 | [MDL Number]
MFCD18916982 | [MOL File]
692739-25-6.mol | [Molecular Weight]
377.26 |
| Hazard Information | Back Directory | [Description]
6-Maleimidocaproic acid PFP ester contains a maleimide and PFP ester end group. Maleimides react with thiol groups within the pH range of 6.5 to 7.5 and form stable thioester bonds. PFP is an activated ester which can react with amine groups to form stable amide bonds. | [Uses]
6-Maleimidocaproic acid-PFP ester is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. | [IC 50]
Alkyl-Chain | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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