| Identification | Back Directory | [Name]
5-chloro-N-(2-ethoxyphenyl)-2-[(4-methoxybenzoyl)amino]benzamide | [CAS]
692774-37-1 | [Synonyms]
BFC1108
5-chloro-N-(2-ethoxyphenyl)-2-[(4-methoxybenzoyl)amino]benzamide
Benzamide, 5-chloro-N-(2-ethoxyphenyl)-2-[(4-methoxybenzoyl)amino]- | [Molecular Formula]
C23H21ClN2O4 | [MOL File]
692774-37-1.mol | [Molecular Weight]
424.88 |
| Chemical Properties | Back Directory | [Boiling point ]
485.0±45.0 °C(Predicted) | [density ]
1.312±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
11.98±0.70(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
BFC1108 is a small molecule Bcl-2 functional converter. BFC1108 induces a conformational change in Bcl-2, resulting in the exposure of its BH3 domain both in vitro and in vivo. BFC1108 effectively induces apoptosis in Bcl-2 expressing cancers.[1]. | [References]
[1] Kopparapu PR, et al. Identification and characterization of a small molecule Bcl-2 Functional Converter. Cancer Res Commun. 2024 Feb 8. DOI:10.1158/2767-9764.CRC-22-0526 |
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