| Identification | Back Directory | [Name]
2-iodo-6-isopropyl-3-methyl-2',4,4'-trinitrodiphenyl ether | [CAS]
69311-70-2 | [Synonyms]
DNP-INT
2-iodo-6-isopropyl-3-methyl-2',4,4'-trinitrodiphenyl ether
4-(2,4-dinitrophenoxy)-3-iodo-2-methyl-1-nitro-5-propan-2-ylbenzene
Benzene, 2-(2,4-dinitrophenoxy)-3-iodo-4-methyl-1-(1-methylethyl)-5-nitro- | [Molecular Formula]
C16H14IN3O7 | [MOL File]
69311-70-2.mol | [Molecular Weight]
487.2 |
| Hazard Information | Back Directory | [Description]
DNP-INT is a quinone analog that inhibits electron transport in plants by competitively inhibiting plastoquinol oxidation by binding at the Qo site of cytochrome b6f (Kd = 1.4 nM).1 It inhibits electron flow from water to NADP or methylviologen by 50 and 100% when used at concentrations of 0.5 or 5 μM, respectively.2,3 | [Uses]
DNP-INT is a potent photosynthetic electron transport chain (PETC) inhibitor. DNP-INT competently inhibits the oxidation of plastid quinoline by binding to the Q0 site of Cyt-b6f (Kd=1.4 nM), thereby inhibiting electron transfer in plants[1]. | [References]
1. Barbagallo, R.P., Finazzi, G., and Forti, G. Effects of inhibitors on the activity of the cytochrome b6f complex: Evidence for the existence of two binding pockets in the lumenal site Biochemistry 38(39),12814-12821(1999).
2. Trebst, A., Wietoska, H., Draber, W., et al. The inhibition of photosynthetic electron flow in chloroplasts by the dinitrophenylether of bromo-or iodo-nitrothymol Z. Naturforsch. C J. Biosci. 33(11-12),919-927(1978).
3. Malkin, R. Interaction of stigmatellin and DNP-INT with the Rieske iron-sulfur center of the chloroplast cytochrome b6f complex. FEBS Lett. 208(2),317-320(1986). |
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