| Identification | Back Directory | [Name]
A 31472 | [CAS]
69319-52-4 | [Synonyms]
A 31472
(5S,4'R)-3-Chloro-N,N-dimethylspiro[5H-dibenzo[a,d]cycloheptene-5,1'-[2]cyclohexen]-4'-amine | [MDL Number]
MFCD32012250 | [MOL File]
69319-52-4.mol |
| Hazard Information | Back Directory | [Description]
A 31472 is a tetracyclic spiro amine that has affinity for dopamine D-2 receptors. These compounds are important for defining the pharmacophore for D-2 antagonist activity due to their limited conformational freedom. | [Uses]
A31472 is a dopamine D-2 receptors antagonist that is promising for research of antipsychotic agents[1]. | [References]
[1] Froimowitz M, et al. Conformational properties of semirigid antipsychotic drugs: the pharmacophore for dopamine D-2 antagonist activity. J Med Chem. 1991 May;34(5):1707-14. DOI:10.1021/jm00109a026 |
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