| Identification | Back Directory | [Name]
MBX2546 | [CAS]
695160-12-4 | [Synonyms]
MBX2546
Acetamide, N-(3,5-dimethylphenyl)-2-[(2-methyl-5-nitrophenyl)(methylsulfonyl)amino]- | [Molecular Formula]
C18H21N3O5S | [MDL Number]
MFCD05817779 | [MOL File]
695160-12-4.mol | [Molecular Weight]
391.44 |
| Chemical Properties | Back Directory | [density ]
1.365±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: 2mg/mL, clear | [form ]
powder | [pka]
12.93±0.70(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
MBX2546 is a influenza A virus inhibitor with the Kd values of 5.3μM and ＞ 100 μM for H1 Hemagglutinin and H3 Hemagglutinin, respectively[1]. | [Biochem/physiol Actions]
MBX2546 is a non-cytotoxic (CC50 >100 μM; 283T) molecule that inhibits against influenza hemagglutinin- (HA-) mediated viral entry (IC90 = 5.7 μM against HIV/HA(H5) entry in 293T culture vs. IC90 >100 μM, 98.2 μM, and >85 μM against HIV/LASV-GP, HIV/EBOV-GP, HIV/VSV-G, respectively) by targeting group 1 HA-specific conformational epitope in the HA stem loop region. MBX2546 is shown to inhibit influenza A strains A/PR/8/34 (H1N1) and A/Florida/21/2008 (H1N1-H275Ψ) (oseltamivir-resistant strain), A/California/10/2009/H1N1, as well as high pathogenic avian influenza (HPAI) strain A/Hong Kong/H5N1 (IC50 = 0.3, 5.8, 0.55-1.5, and 3.6 μM, respectively), but not A/Texas/12/2007 (H3N2), A/Perth/16/2009 (H3N2), A/Victoria/3/75 (H3N2), A/Panama/2007/99 (H3N2), A/Sydney/05/97 (H3N2), A/California/7/04 (H3N2), A/Wyoming/03/2003 (H3N2), or influenza B strain B/Florida/4/2006 in MDCK cultures. | [References]
[1] Basu A, et al. Molecular Mechanism Underlying the Action of Influenza A Virus Fusion Inhibitor MBX2546. ACS Infect Dis. 2017 May 12;3(5):330-335. DOI:10.1021/acsinfecdis.6b00194 |
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Sigma-Aldrich
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Merck KGaA
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www.sigmaaldrich.cn |
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