69697-46-7

950771-91-2

69697-46-7

The general procedure for the synthesis of 4-isopropoxycyclohexanone from 8-isopropoxy-1,4-dioxaspiro[4.5]decane was carried out as follows: a tetrahydrofuran solution (10 ml) of 8-isopropoxy-1,4-dioxaspiro[4.5]decane and 4-isopropoxycyclohexanone (approx. 4:1 mixture, D25, 4.89 g, approx. 0.025 mol) was prepared at room temperature and under argon protection ) was treated with 5 M hydrochloric acid (50 ml) and stirred thoroughly for 18 hours. After completion of the reaction, the reaction mixture was diluted with water (150 ml) and extracted with dichloromethane (2 x 80 ml). The organic phases were combined, washed with brine, dried over anhydrous sodium sulfate, and subsequently concentrated under vacuum to give 4-isopropoxycyclohexanone as a colorless oil (3.9 g, 100% yield).1H NMR (CDCl3, 400 MHz) δ: 1.19 (6H, d), 1.88-2.08 (4H, m), 2.22-2.32 (2H, m), 2.54- 2.65 (2H, m), 3.70-3.84 (2H, m).