697739-13-2

697739-12-1

697739-13-2

1. ethyl imidazo[1,5-a]pyridine-8-carboxylate (8.67 g, 45.6 mmol) and potassium hydroxide (91.2 ml, 91.2 mmol, 1 M methanol solution) were mixed in a reaction vial. 2. The reaction mixture was heated and refluxed for 30 min, and the progress of the reaction was monitored by HPLC until the reaction was complete. 3. Upon completion of the reaction, the mixture was cooled and concentrated to dryness in a rotary evaporation The mixture was concentrated to dryness in a rotary evaporator.4. Water (50 ml) was added to the residue, which was subsequently acidified with 2N hydrochloric acid solution to pH<7, where a yellow precipitate was formed.5. The precipitate was collected by filtration and washed with water, ethanol, and ether in that order.6. After drying, imidazo[1,5-A]pyridine-8-carboxylic acid (3.1 g, 42% yield) was obtained as a yellow solid.