| Chemical Properties | Back Directory | [Melting point ]
170-174°C | [storage temp. ]
-20°C Freezer | [solubility ]
DMF: 5 mg/ml,DMSO: 5 mg/ml,DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml,Ethanol: 1.5 mg/ml | [form ]
A crystalline solid |
| Hazard Information | Back Directory | [Description]
Docetaxel is a semisynthetic analog of taxol that inhibits microtubule disassembly (IC50 = 0.2 μM) and inhibits cell replication (IC50 = 0.13 μM). It has proven more effective than taxol in preventing the proliferation of cancer cells. Docetaxel has applications in breast cancer and hormone-refractory prostate cancer. This product is intended for research applications. | [Chemical Properties]
White Solid | [Uses]
A semisynthetic derivative of Paclitaxel(P132500), an antimitotic agent that promotes the assembly of micro-tubules and inhibits their de-polymerization to free tubulin. An antine oplastic. | [Uses]
A semisynthetic derivative of Paclitaxel. An antimitotic agent that promotes the assembly of micro-tubules and inhibits their de-polymerization to free tubulin. An antineoplastic. | [References]
[1] M C BISSERY. Experimental antitumor activity of taxotere (RP 56976, NSC 628503), a taxol analogue.[J]. Cancer research, 1991, 51 18: 4845-4852.
[2] CHARLES S. SWINDELL *. Characterization of the taxol structure-activity profile for the locus of the A-ring side chain[J]. Bioorganic & Medicinal Chemistry Letters, 1994, 4 12: Pages 1531-1536. DOI: 10.1016/s0960-894x(01)80527-8
[3] STEVEN P ZIELSKE. SNHG1 opposes quiescence and promotes docetaxel sensitivity in prostate cancer.[J]. BMC Cancer, 2023, 23 1: 672. DOI: 10.1186/s12885-023-11006-x
[4] RAHUL KUMAR. Cytochrome c Deficiency Confers Apoptosome and Mitochondrial Dysfunction in African-American Men with Prostate Cancer.[J]. Cancer research, 2019: 1353-1368. DOI: 10.1158/0008-5472.can-18-2383 |
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