| Identification | Back Directory | [Name]
SBI-0136892 | [CAS]
701929-65-9 | [Synonyms]
SBI-0136892
Nampt activator-1
ethyl 4-(3-(pyridin-4-ylmethyl)ureido)benzoate
Benzoic acid, 4-[[[(4-pyridinylmethyl)amino]carbonyl]amino]-, ethyl ester | [Molecular Formula]
C16H17N3O3 | [MOL File]
701929-65-9.mol | [Molecular Weight]
299.32 |
| Chemical Properties | Back Directory | [Boiling point ]
471.6±45.0 °C(Predicted) | [density ]
1.248±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
12.31±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
Nampt activator-1 (compound 1) is a potent Nicotinamide phosphoribosyltransferase (NAMPT) activator, with EC50 of 3.3-3.7 μM[1]. | [References]
[1] Akiu M, et al. Discovery of 1-[2-(1-methyl-1H-pyrazol-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-3-(pyridin-4-ylmethyl)urea as a potent NAMPT (nicotinamide phosphoribosyltransferase) activator with attenuated CYP inhibition.[J]. Bioorganic & medicinal chemistry letters, 2021, 43:128048. |
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