| Identification | Back Directory | [Name]
diethadione | [CAS]
702-54-5 | [Synonyms]
Toce
L-1811
Dioxone
Ledosten
HSDB 5514
Diethadion
diethadione
Diethadionum
5,5-diethyl-1,3-oxazinane-2,4-dione
5,5-diethyl-1,3-oxazinane-2,4-quinone
2H-1,3-Oxazine-2,4(3H)-dione, 5,5-diethyldihydro- | [EINECS(EC#)]
211-867-1 | [Molecular Formula]
C8H13NO3 | [MDL Number]
MFCD00864194 | [MOL File]
702-54-5.mol | [Molecular Weight]
171.19 |
| Safety Data | Back Directory | [TSCA ]
TSCA listed | [Safety Profile]
Poison by ingestion,
intravenous, intraperitoneal, subcutaneous,
and intramuscular routes. An analeptic (central nervous system stimulant). When heated to decomposition it emits toxic
fumes of NOx
| [Hazardous Substances Data]
702-54-5(Hazardous Substances Data) | [Toxicity]
LD50 in mice, rats (mg/kg): 52, 31.6 i.p.; 130, 70.5 orally (Maffii) |
| Hazard Information | Back Directory | [Uses]
Dioxone is a substance possessing convulsant properties qualitatively similar to leptazol and bemegride. Dioxone is orally active[1]. | [Definition]
ChEBI: Diethadione is an oxazinane. | [in vivo]
Dioxone (0-30 mg/kg; i.v., i.p., oral, s.c.; once) induces convulsant action[1]. | Animal Model: | CF-1 Mice and CF-Wistar rats[1] | | Dosage: | 0-30 mg/kg | | Administration: | Intraperitoneal injection, once | | Result: | In mice: The spontaneous activity was often reduced, always accompanied by hyperreactivity at 10 mg/kg, tremors, clonic convulsion and motor incoordination phenomena occured after the administration of 30 mg/kg. In rats: Tremors and some isolated clonus of the muscles of the limbs were observed with 10 mg/kg, clonic convukions occurred with doses above 15 mg/kg. |
| [References]
[1] G MAFFII, et al. A new analeptic: 5, 5-diethyl-1, 3-oxazine-2,4-dione (Dioxone). J Pharm Pharmacol. 1961 Apr;13:244-53. DOI:10.1111/j.2042-7158.1961.tb11818.x |
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| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|