| Identification | Back Directory | [Name]
(S)-2-((S)-2-(tert-butoxycarbonylaMino)-3-MethylbutanaMido)propanoic acid | [CAS]
70396-18-8 | [Synonyms]
Boc-Val-Ala
Boc-L-Valyl- L-Alanin
N-Boc-L-valyl- L-alanine
(Tert-Butoxy)Carbonyl Val-Ala-OH
(tert-Butoxycarbonyl)-L-valyl-L-alanine
L-Alanine, N-[(1,1-dimethylethoxy)carbonyl]-L-valyl-
(S)-2-((S)-2-(tert-butoxycarbonylaMino)-3-MethylbutanaMido)propanoic acid
(2S)-2-[(2S)-2-{[(tert-butoxy)carbonyl]amino}-3-methylbutanamido]propanoic acid | [Molecular Formula]
C13H24N2O5 | [MDL Number]
MFCD22381612 | [MOL File]
70396-18-8.mol | [Molecular Weight]
288.34 |
| Chemical Properties | Back Directory | [Boiling point ]
493.3±30.0 °C(Predicted) | [density ]
1.121±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [form ]
Solid | [pka]
3.50±0.10(Predicted) | [color ]
White to off-white | [InChI]
InChI=1S/C13H24N2O5/c1-7(2)9(10(16)14-8(3)11(17)18)15-12(19)20-13(4,5)6/h7-9H,1-6H3,(H,14,16)(H,15,19)(H,17,18)/t8-,9-/m0/s1 | [InChIKey]
FHBCSPANXVQYCP-IUCAKERBSA-N | [SMILES]
C(O)(=O)[C@H](C)NC(=O)[C@H](C(C)C)NC(OC(C)(C)C)=O |
| Hazard Information | Back Directory | [Description]
Boc-Val-Ala-OH is a cleavable ADC linker. The Val-Ala is effectively cleaved by lysosomal proteolytic enzymes while being highly stable in human plasma, making this a potentent stragy in ADC linker design. The Boc group can be deprotected under mild acidic conditions to form the free amine. | [Uses]
(tert-Butoxycarbonyl)-L-valyl-L-alanine is an alanine derivative[1]. | [References]
[1] Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1080. DOI:10.1080/10408398.2012.708368 |
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