| Identification | Back Directory | [Name]
Aligeron | [CAS]
70713-45-0 | [Synonyms]
Aligeron
Piperazine, 1-(diphenylmethyl)-4-(2-propen-1-yl)- | [Molecular Formula]
C20H24N2 | [MDL Number]
MFCD01702918 | [MOL File]
70713-45-0.mol | [Molecular Weight]
292.424 |
| Chemical Properties | Back Directory | [Boiling point ]
390.6±37.0 °C(Predicted) | [density ]
1.044±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
6.79±0.10(Predicted) |
| Hazard Information | Back Directory | [Uses]
Aligeron is a non-selective prostaglandin (PG) antagonist, and has vasodilatory properties. | [in vivo]
In hypoventilation hypoxia, aligeron (5 mg/kg i.v.) and cinnarizine increase cortical resistance to hypoxia and accelerated the recovery of cortical bioelectrical activity. In KCl- and AMP-induced depressions aligeron shows a protective effect manifested in a decrease of the degree and duration of the depression[2]. | [References]
[1] Miyares K, et al. Antagonistic activity of aligeron and papaverine against different smooth muscle stimuli. Methods Find Exp Clin Pharmacol. 1985 Sep;7(9):473-6. PMID:4079597
[2] Dimov S, et al. Effect of aligeron and cinnarizine in models of general and local depression of the cortical bioelectrical activity in cats. Methods Find Exp Clin Pharmacol. 1983;5(2):89-95. PMID:6308367 |
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