| Identification | Back Directory | [Name]
(+/-)-THIOPENTAL SODIUM SALT/SODIUM CARBONATE | [CAS]
71-73-8 | [Synonyms]
ravonal
farmotal
trapanal
hypnostan
leopental
thionembutal
Thiopentemal
thiothalsodium
intravalsodium
nesdonalsodium
trapanalsodium
tiopentalsodium
pentothalsodium
sodiumpentothal
thipentalsodium
sodiumthiopental
sodiumthiopentone
thiopentonesodium
thiomebumalsodium
Sodium Carbpnate
THIOPENTAL SODIUM
Intra-Vital Sodium
solublethiopentone
Thionembutal sodium
RS-Thiopental sodium
sodiumpenthiobarbital
penthiobarbitalsodium
THIOPENTAL SODIUM SALT
sodiumpentothiobarbital
sodiumthiopentobarbital
Thiopentone, sodium salt
Thiopentobarbitone sodium
Thiopental Sodium USP/EP/BP
PENTOTHAL SODIUM-POTASSIUM SALT
Thiopental sodium(for injection)
Thiopental Sodium Sterile (API & Vials)
(+/-)-THIOPENTAL SODIUM SALT/SODIUM CARBONATE
(+/-)-THIOPENTAL SODIUM SALT/SODIUM CARBONATE
Thiopental sodium and sodium carbonate sterile
sodium5-ethyl-5-(1-methylbutyl)-2-thiobarbiturate
monosodium5-ethyl-5-(1-methylbutyl)thiobarbiturate
5-Ethyl-5-(1-methylbutyl)-2-thiobarbutyrate sodium
Sodium 5-ethyl-5-(a-methylbutyl)-2-thiobarbiturate
(+,-)-THIOPENTAL SODIUM/SODIUM*CARBONATE --DEA SCHED
(+/-)-THIOPENTAL SODIUM SALT-SODIUM CARBONATE MIXTURE
5-ethyl-5-(1-methylbutyl)-2-thiobarbituricacidmonosodium
5-ethyl-5-(1-methylbutyl)-2-thio-barbituricacisodiumsalt
5-Ethyl-5-[1-methylbutyl]-2-thiobarbituric acid, sodium salt
(+/-)-Thiopental SodiuM Salt-SodiuM Carbonate Mixture (CIII)
5-Ethyl-5-(1-methylbutyl)-2-thiobarbituric acid, Pentothal
THIOPENTAL SODIUM/SODIUM CARBONATE MIXTU RE >96% INTRAVENOUS AN
5-ETHYL-5-(1-METHYLBUTYL)-2-THIOBARBITURIC ACID SODIUM-POTASSIUM SALT
Barbituric acid, 5-ethyl-5-(1-methylbutyl)-2-thio-, sodium salt (8CI)
Barbituric acid, 5-ethyl-5-(1-methylbutyl)-2-thio-, sodium deriv. (7CI)
6(1h,5h)-pyrimidinedione,5-ethyldihydro-5-(1-methylbutyl)-2-thioxo-monos
6(1h,5h)-pyrimidinedione,5-ethyldihydro-5-(1-methylbutyl)-2-thioxo-monosod
5-ETHYL-5-[1-METHYLBUTYL]-2-THIOBARBITURIC ACID SODIUM SALT/SODIUM CARBONATE
5-Ethyldihydro-5-(1-methylbutyl)-2-thioxo-4,6(1H,5H)-pyrimidinedione sodium salt
5-Ethyldihydro-5-(1-methylbutyl)-2-thioxo-4,6(1H,5H)-pyrimidinedione monosodium salt
4,6(1H,5H)-Pyrimidinedione, 5-ethyldihydro-5-(1-methylbutyl)-2-thioxo-, monosodium salt
4,6(1H,5H)-PyriMidinedione,5-ethyldihydro-5-(1-Methylbutyl)-2-thioxo-, sodiuM salt (1:1)
4,6(1H,5H)-Pyrimidinedione, 5-ethyldihydro-5-(1-methylbutyl)-2-thioxo-, monosodium salt (9CI)
Thiopental SodiumQ: What is
Thiopental Sodium Q: What is the CAS Number of
Thiopental Sodium Q: What is the storage condition of
Thiopental Sodium Q: What are the applications of
Thiopental Sodium | [EINECS(EC#)]
200-763-1 | [Molecular Formula]
C11H17N2NaO2S | [MDL Number]
MFCD00072013 | [MOL File]
71-73-8.mol | [Molecular Weight]
264.32 |
| Hazard Information | Back Directory | [Chemical Properties]
Yellowish-white, hygroscopic powder. | [Uses]
Pentothal (Abbott). | [Definition]
A rapidly acting barbiturate administered
intravenously for general anesthesia and hypnosis.
Commonly known as “truth serum.” | [Brand name]
Thiopental is BAN. | [Hazard]
May cause respiratory failure; use onlywith
physician in attendance. | [Description]
Thiopental sodium , the sodium
salt of 5-ethyl-5-(1-methylbutyl)thiobarbituric
acid, a yellowish-white,
crystalline, slightly bitter powder, is very soluble
in water and soluble in alcohol. The compound
is hygroscopic and has a weak unpleasant
odor. The free acid forms colorless crystals, mp
158 – 159 ?C.A10%solution of the sodium salt
has a pH of 10.6. | [History]
Sodium thiopental was first synthesised in the early 1930s by Ernest H. Volwiler and Donalee L. Tabern at Abbott Laboratories. Owing to its rapid onset of action, Ralph M. Waters first administered sodium thiopental for human anaesthesia on 8 March 1934. | [General Description]
Thiopental sodium is an organic sodium salt having thiopental(1) as the counter-ion. It has a role as an intravenous anaesthetic. It contains a thiopental(1-). | [Pharmacokinetics]
Thiopental is highly bound to albumin, and free drug availability is increased
in hypoproteinaemia. Protein binding is decreased by alkalaemia,
hyperventilation and some drugs that occupy the same albumin binding
sites, thereby increasing unbound thiopental concentrations. Metabolism
occurs predominantly in the liver, and the metabolites are excreted by the
kidneys. Only a small proportion is excreted unchanged in the urine. The
terminal elimination half-life is approximately 11.5h (longer in the elderly).
Elimination after an infusion is a zero-order process with 10%–15% of the
remaining drug metabolised each hour. Up to 30% of the original dose may
remain in the body at 24h, and a hangover effect is common. Accumulation
may result if further doses of thiopental are administered within 1–2 days. | [Clinical Use]
Thiopental sodium is a short-acting intravenous
anesthetic used for brief surgical procedures
and induction of anesthesia. It is a potent,rapidly effective hypnotic. Sleep ensues within
30 – 60 s. A disadvantage is the lengthy hangover.
In the United States and Great Britain it is
the most widely used injection anesthetic. Abuse
can lead to addiction. | [Veterinary Drugs and Treatments]
Because of its rapid action and short duration, in young, healthy
animals, thiopental is excellent induction agent (rapid IV bolus)
for general anesthesia with other anesthetics or as the sole anesthetic
agent for very short procedures. In sick or debilitated animals,
thiopental may be used in a more cautious manner (IV, slowly to
effect). |
| Safety Data | Back Directory | [Hazard Codes ]
T | [Risk Statements ]
25 | [Safety Statements ]
36-45 | [RIDADR ]
UN 2811 6.1/PG 3
| [WGK Germany ]
3
| [RTECS ]
CQ6475000
| [HazardClass ]
6.1(b) | [PackingGroup ]
III | [Safety Profile]
Poison by ingestion, intraperitoneal, rectal, subcutaneous, and intravenous routes. Human systemic effects by intraarterial route: acute arterial occlusion; by rectal route: respiratory depression, body temperature decrease, general anesthetic. An experimental teratogen. Experimental reproductive effects. An intravenous anesthetic. When heated to decomposition it emits toxic fumes of NO, and Na2O. See also PENTOTHAL and BARBITURATES | [Toxicity]
LD50 in mice (mg/kg): 149 i.p.; 78 i.v. (Christensen, Lee) |
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