| Identification | Back Directory | [Name]
2-Pyridinamine, 5-[(2R,5S)-5-methyl-4-propyl-2-morpholinyl]- | [CAS]
710655-15-5 | [Synonyms]
PF592379,PF 592379
2-Pyridinamine, 5-[(2R,5S)-5-methyl-4-propyl-2-morpholinyl]- | [Molecular Formula]
C13H21N3O | [MDL Number]
MFCD31382109 | [MOL File]
710655-15-5.mol | [Molecular Weight]
235.325 |
| Chemical Properties | Back Directory | [Boiling point ]
377.0±42.0 °C(Predicted) | [density ]
1.058±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
Soluble in DMSO | [pka]
7.47±0.40(Predicted) |
| Hazard Information | Back Directory | [Uses]
PF-592379 is a potent dopamine D3 receptor agonist with an EC50 of 21 nM. | [in vivo]
PF-592379 is an oral dopamine 3 agonist in rat, and dog. PF-592379 has low-moderate clearance relative to liver blood flow of 6.3 and 8.5 mL/min/kg in dog and 44.8 and 58.2 mL/min/kg in rat. It has high permeability in Caco-2 cells and is completely absorbed in rat and dog pharmacokinetic studies with an oral bioavailability of 28% in both rats and 61 and 87% in the dogs[1]. | [References]
[1] Attkins N, et al. Pharmacokinetics and elucidation of the rates and routes of N-glucuronidation of PF-592379, an oral dopamine 3 agonist in rat, dog, and human. Xenobiotica. 2010 Nov;40(11):730-42. DOI:10.3109/00498254.2010.514961
[2] Wager TT, et al. Dopamine D3/D2 Receptor Antagonist PF-4363467 Attenuates Opioid Drug-Seeking Behavior without Concomitant D2 Side Effects. ACS Chem Neurosci. 2017 Jan 18;8(1):165-177. DOI:10.1021/acschemneuro.6b00297
[3] Collins GT, et al. Lack of abuse potential in a highly selective dopamine D3 agonist, PF-592,379, in drug self-administration and drug discrimination in rats. Behav Pharmacol. 2012 Jun;23(3):280-91. DOI:10.1097/FBP.0b013e3283536d21 |
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