| Identification | Back Directory | [Name]
FOY 251 | [CAS]
71079-09-9 | [Synonyms]
FOY 251
FOY-251 mesylate
FOY 251（Camostat metabolite）
4-(4-guanidinobenzoyloxy)phenylacetic acid
4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]-benzeneacetic Acid Monomethanesulfonat
4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]-benzeneacetic Acid Monomethanesulfonate | [Molecular Formula]
C17H19N3O7S | [MDL Number]
MFCD09842546 | [MOL File]
71079-09-9.mol | [Molecular Weight]
409.41 |
| Chemical Properties | Back Directory | [Melting point ]
194-198°C | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [color ]
White to Off-White | [Water Solubility ]
Water: < 0.1 mg/mL (insoluble) | [InChIKey]
JXMOPIDYHUYOED-UHFFFAOYSA-N | [SMILES]
O=C(C1=CC=C(NC(N)=N)C=C1)OC2=CC=C(CC(O)=O)C=C2.O=S(O)(C)=O |
| Hazard Information | Back Directory | [Chemical Properties]
White Solid | [Uses]
A metabolite of Camostat. It is a pollen protease inhibitor for prevention and control of allergy | [Biological Activity]
Trypsin-like serine protease inhibitor Camost at (FOY-305) active metabolite with inhibitory potency against transmembrane serine protease 2 (TMPRSS2).
FOY-251 is a trypsin-like serine protease inhibitor and an active metabolite of the oral drug Camostat/FOY-305 (trypsin IC50 = 51/55 nM by FOY-305/FOY-251; plasma kallikrein/plasmin IC50 = 1.48/2.64 μM by FOY-305 and 2.32/12.5 μM by FOY-251). FOY-251 and FOY-305 are also potent inhibitor against transmembrane serine protease 2 (TMPRSS2 IC50 = 6.2/33.3 nM by by FOY-305/FOY-251) th at primes SARS-CoV-2 spike protein for host cell entry. |
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