| Identification | Back Directory | [Name]
Carbodine | [CAS]
71184-20-8 | [Synonyms]
C-Cyd
Carbodine
Carbodine (Carbocyclic cytidine)
4-Amino-1-[(1R)-2α,3α-dihydroxy-4β-(hydroxymethyl)cyclopentan-1β-yl]-2(1H)-pyrimidinone
2(1H)-Pyrimidinone, 4-amino-1-[(1R,2S,3R,4R)-2,3-dihydroxy-4-(hydroxymethyl)cyclopentyl]- | [Molecular Formula]
C10H15N3O4 | [MDL Number]
MFCD09838338 | [MOL File]
71184-20-8.mol | [Molecular Weight]
241.24 |
| Hazard Information | Back Directory | [Uses]
Carbodine (Carbocyclic cytidine) is a broad-spectrum antiviral agent active against DNA viruses, (+)RNA viruses, (-)RNA viruses, paramyxo, rhabdo and (+/-)RNA viruses, targets CTP synthetase that converts UTP to CTP. Carbodine (Carbocyclic cytidine) possesses significant antiviral activity against influenza virus types A0/PR-8/34 and A2/Aichi/2/68 in vitro[1][2]. | [References]
[1] De Clercq E, et al. Broad-spectrum antiviral activity of carbodine, the carbocyclic analogue of cytidine. Biochem Pharmacol. 1990 Jan 15;39(2):319-25. DOI:10.1016/0006-2952(90)90031-f
[2] Shannon WM, et al. Evaluation of carbodine, the carbocyclic analog of cytidine, and related carbocyclic analogs of pyrimidine nucleosides for antiviral activity against human influenza Type A viruses. Antimicrob Agents Chemother. 1981 Dec;20(6):769-76. DOI:10.1128/AAC.20.6.769 |
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