| Identification | Back Directory | [Name]
ML 141 | [CAS]
71203-35-5 | [Synonyms]
ML 141
CS-1743
CID-2950007
ML141;ML 141
ML 141 USP/EP/BP
ML141(CID-2950007)
ML141;ML 141;CID-2950007
Cdc42/Rac1 GTPase Inhibitor, ML141 - Calbiochem
5-(4-Methoxyphenyl)-1-(4-sulfamoylphenyl)-3-phenyl-2-pyrazoline
4-[3-(4-Methoxyphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]benzenesulfonamide
4-(5-(4-methoxyphenyl)-3-phenyl-4,5-dihydropyrazol-1-yl)benzenesulfonamide
4-(5-(4-methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide
4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]-benzenesulfonamide
Benzenesulfonamide, 4-[4,5-dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]-
4-[2-(1-PIPERIDINYL)ETHYL]-3,4-DIHYDRO-2H-PYRIDO[3,2-B][1,4]OXAZINE TRIHYDROCHLORIDE
4-[4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl]-benzenesulfonamide ML141 | [Molecular Formula]
C22H21N3O3S | [MDL Number]
MFCD05987165 | [MOL File]
71203-35-5.mol | [Molecular Weight]
407.49 |
| Chemical Properties | Back Directory | [Melting point ]
216 °C(Solv: ethanol (64-17-5)) | [Boiling point ]
622.9±65.0 °C(Predicted) | [density ]
1.31±0.1 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
DMSO: soluble5mg/mL (warmed, clear solution) | [form ]
Yellow-white solid | [pka]
10.39±0.10(Predicted) | [color ]
white to beige |
| Hazard Information | Back Directory | [Uses]
ML 141 has been used:
- to inhibit CDC42 GTPase in human immortalized gingival epithelial (HIGE) cells
- as inhibitors of Rho kinase to study the role of small Rho GTPases on localization of peripheral nuclei
- as actin regulator inhibitor, to determine which actin regulators and nucleators are involved in the assembly of F-actin cages around damaged mitochondria
- as a selective, non-competitive inhibitor of Cdc42 to treat CCD-1070Sk cells
| [Definition]
ChEBI: 4-[3-(4-methoxyphenyl)-5-phenyl-3,4-dihydropyrazol-2-yl]benzenesulfonamide is a sulfonamide. | [Biochem/physiol Actions]
ML 141 is a potent, selective inhibitor of the Rho family GTPase cdc42. The IC50 for inhibition of enzymatic activity is 200 nM, with no activity against Rho family members Rac, Ras or Rab. Cdc42 has been implicated in the regulation of actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. This complex mediates the polymerization of actin into branched networks and regulates important functions including cell adhesion, cytoskeletal arrangement, phagocytosis and host-pathogen interactions, motility, migration, and membrane protein trafficking. | [in vivo]
ML141 (CID-2950007) (10 μM; intracerebroventricular injection) causes acute anxiety in mice[3]. | Animal Model: | C57Bl/6J mice[3] | | Dosage: | 10 μM | | Administration: | Intracerebroventricular injection | | Result: | Increased anxiety in mice.
|
| [storage]
Store at +4°C |
|
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
D&C Chemicals
|
| Tel: |
+86-21-58447131 |
| Website: |
www.chemicalbook.com/ShowSupplierProductsList16963/0_EN.htm |
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